{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:01:55Z","timestamp":1772118115270,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T00:00:00Z","timestamp":1669766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aimed to investigate if there is a significant difference in peripheral insulin\u2010like growth factor 1 (IGF\u20101) levels between schizophrenia patients and healthy controls and to determine whether a difference exists before and after initiation of antipsychotics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PubMed\/MEDLINE, Scopus, and Web of Science were searched up to March 27, 2022. Original clinical studies of any type that reported peripheral blood, serum or plasma IGF\u20101 levels measured after fasting in schizophrenia patients and\/or healthy control group were selected based on inclusion and exclusion criteria. Data were analyzed using Meta\u2010Essentials: Workbooks for meta\u2010analysis and pooled through random\u2010effects meta\u2010analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twelve publications met eligibility criteria. Schizophrenia patients under antipsychotic treatment had significantly lower peripheral IGF\u20101 levels compared to healthy controls (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0632, Hedges\u2019 g \u20130.42, 95% CI from \u20130.79 to \u20130.04,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.006, I\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a070.38%), while no significant difference was found between schizophrenia patients regardless of the antipsychotic treatment status and healthy controls, as well as between antipsychotic na\u00efve or free schizophrenia patients and healthy controls, and before and after initiation of antipsychotic treatment. However, high heterogeneity was observed and its potential sources in some of the subgroup analyses included sample type and region.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Schizophrenia patients under antipsychotic treatment seem to have lower peripheral IGF\u20101 levels compared to healthy controls. Additional studies with larger and more homogenous samples are needed to confirm these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.2819","type":"journal-article","created":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T10:30:19Z","timestamp":1669804219000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Meta\u2010analysis of peripheral insulin\u2010like growth factor 1 levels in schizophrenia"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1741-0025","authenticated-orcid":false,"given":"Ana V.","family":"Pejcic","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Medical Sciences University of Kragujevac  Kragujevac Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Slobodan M.","family":"Jankovic","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Medical Sciences University of Kragujevac  Kragujevac Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir","family":"Janjic","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Faculty of Medical Sciences University of Kragujevac  Kragujevac Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milan","family":"Djordjic","sequence":"additional","affiliation":[{"name":"Department of Communication Skills, Ethics and Psychology, Faculty of Medical Sciences University of Kragujevac  Kragujevac Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jovana Z.","family":"Milosavljevic","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Faculty of Medical Sciences University of Kragujevac  Kragujevac Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milos N.","family":"Milosavljevic","sequence":"additional","affiliation":[{"name":"Department of 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