{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T05:12:36Z","timestamp":1791609156295,"version":"4.3.4"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,10]],"date-time":"2022-12-10T00:00:00Z","timestamp":1670630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and purpose<\/jats:title>\n                    <jats:p>The impact of sex and age on prognosis in patients with intracerebral hemorrhage (ICH) in the Chinese population remains unclear. Our study aimed to investigate the relationship between sex and age of Chinese ICH patients and adverse prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used the Chinese Stroke Center Alliance database with in\u2010hospital mortality as the primary outcome and hospital complications as the secondary outcome. Patients were divided into four groups by sex and age. Logistic regression analyses were performed to assess the association between sex and age and the prognosis of ICH patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We enrolled 60,911 ICH patients, including 22,284 young and middle\u2010aged males, 15,651 older males, 11,948 young and middle\u2010aged females, and 11,028 older females. After adjusting for variables, older male patients had a higher mortality rate (OR\u00a0=\u00a01.21, 95% CI 1.01\u20131.45), combined with more frequent hematoma expansion (OR\u00a0=\u00a01.14, 95% CI 1.03\u20131.26), pneumonia (OR\u00a0=\u00a01.91, 95% CI 1.81\u20132.03), and hydrocephalus (OR\u00a0=\u00a01.28, 95% CI 1.04\u20131.59). Young and middle\u2010aged female patients had a lower mortality rate (OR\u00a0=\u00a00.74, 95% CI 0.58\u20130.95) and less frequent combined pneumonia (OR\u00a0=\u00a00.81, 95% CI 0.75\u20130.87). In\u2010hospital mortality was not significantly different in older females compared with young and middle\u2010aged males, but the odds of deep vein thrombosis, swallowing disorders, urinary tract infections, and gastrointestinal bleeding were significantly higher.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Among young and middle\u2010aged patients, females are related to a lower in\u2010hospital mortality rate from ICH. Older patients are at an increased risk of ICH complications, with higher in\u2010hospital mortality in older men.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.2846","type":"journal-article","created":{"date-parts":[[2022,12,10]],"date-time":"2022-12-10T06:03:49Z","timestamp":1670652229000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Association of sex and age with in\u2010hospital mortality and complications of patients with intracerebral hemorrhage: A study from the Chinese Stroke Center Alliance"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1962-588X","authenticated-orcid":false,"given":"Ping","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Neurology Beijing Tiantan Hospital Capital Medical University  Beijing People's Republic of 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