{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:26:04Z","timestamp":1791645964603,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T00:00:00Z","timestamp":1672099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Postoperative cognitive dysfunction (POCD) is a severe postoperative neurological sequela in elderly patients, and there is currently no standard treatment for POCD. In this study, whether recombinant human heat shock protein 70 (rHsp70) could alleviate sevoflurane\u2010induced cognitive impairment in aged mice is investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To determine the prophylactic effect of rHsp70 in sevoflurane\u2010induced cognitive dysfunction, aged mice were pretreated with different concentrations of rHsp70 (29.4, 58.8, and 117.6\u00a0\u03bcg\/kg; intranasal injected; N\u00a0=\u00a012) every day for 1 week; then, 3% sevoflurane was utilized to anesthetize the aged mice. Cognitive function, neurotoxicity, and serum and hippocampal Hsp70 levels in aged mice undergoing sevoflurane anesthesia were assessed by the Morris water maze test and enzyme\u2010linked immunosorbent assay. The effects of rHsp70 on inflammatory response were assessed by proinflammatory cytokine production and nuclear factor\u2010\u03baB (NF\u2010\u03baB) activation assays.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that aged mice exposed to sevoflurane showed reduced learning and memory ability and reduced Hsp70 expression, which were both restored by rHsp70 pretreatment. RHsp70 also reversed sevoflurane\u2010induced up\u2010regulated Bax and Bcl\u20102 expression and interleukin\u20101, IL\u20106, and monocyte chemoattractant protein\u20101 overproduction. Finally, rHsp70 pretreatment suppressed sevoflurane\u2010induced NF\u2010\u03baB activation. Our study indicated that rHsp70 was sufficient to suppress sevoflurane\u2010induced cognitive decline and neurotoxicity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our important finding warrants further study on the clinical application of rHsp70 in elderly patients undergoing anesthesia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.2861","type":"journal-article","created":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T13:29:01Z","timestamp":1672147741000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Exogenous recombinant Hsp70 attenuates sevoflurane anesthesia\u2010induced cognitive dysfunction in aged mice"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5303-3103","authenticated-orcid":false,"given":"Yongxiang","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Longyan People Hospital of Fujian  Longyan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianzhong","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Zhangzhou Affiliated Hospital of Fujian Medical University  Zhangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijia","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Longyan People Hospital of Fujian  Longyan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1516131112"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-130779"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2020.08.030"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3233\/RNN-201022"},{"key":"e_1_2_8_6_1","first-page":"e161","article-title":"Heat shock proteins: Biological functions, pathological roles, and therapeutic opportunities","volume":"3","author":"Hu C.","year":"2022","journal-title":"Medicine Communications"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.12.097"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-011-0115-3"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X1804600610"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.116747"},{"key":"e_1_2_8_11_1","first-page":"3085","article-title":"Rapamycin improves sevofluraneinduced cognitive dysfunction in aged rats by mediating autophagy through the TLR4\/MyD88\/NF\u2010\u03baB signaling pathway","volume":"20","author":"Li Y.","year":"2019","journal-title":"Molecular Medicine Reports"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-020-02332-w"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-020-03070-7"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871527317666180827111152"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3410\/M1-14"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.4097\/kjae.2015.68.4.397"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.4065\/mcp.2011.0332"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/618127"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0216372"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21548"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2020.134785"},{"key":"e_1_2_8_22_1","first-page":"5091","article-title":"Neuroprotective effect of CTRP3 overexpression against sevoflurane anesthesia\u2010induced cognitive dysfunction in aged rats through activating AMPK\/SIRT1 and PI3K\/AKT signaling pathways","volume":"24","author":"Yang L. H.","year":"2020","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"e_1_2_8_23_1","first-page":"5082","article-title":"Sevoflurane inhibits neuronal apoptosis and expressions of HIF\u20101 and HSP70 in brain tissues of rats with cerebral ischemia\/reperfusion injury","volume":"24","author":"Yu F.","year":"2020","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2017.11.013"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/ggi.13619"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2018.05.059"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.2861","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/brb3.2861","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.2861","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T09:19:36Z","timestamp":1692350376000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.2861"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,27]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1002\/brb3.2861"],"URL":"https:\/\/doi.org\/10.1002\/brb3.2861","archive":["Portico"],"relation":{},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,27]]},"assertion":[{"value":"2022-08-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2861"}}