{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T16:15:14Z","timestamp":1776356114195,"version":"3.51.2"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T00:00:00Z","timestamp":1672876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Juvenile myoclonic epilepsy (JME) is characterized by generalized seizures. Nearly 30% of JME patients are drug\u2010resistant (DR\u2010JME), indicating a widespread cortical dysfunction. Walking is an important function that necessitates orchestrated coordination of frontocentral cortical regions. However, gait alterations in JME have been scarcely investigated. Our aim was to assess changes in gait and motor\u2010evoked responses in DR\u2010JME patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty\u2010nine subjects (11 JME drug\u2010responder, 8 DR\u2010JME, and 10 healthy controls) underwent a gait analyses during usual walking and dual\u2010task walking. Later, subjects underwent 64\u2010channel EEG recordings while performing a simple motor task. We calculated the motor\u2010evoked current source densities (CSD) at a priori chosen cortical regions. Gait and CSD measures were compared between groups and tasks using mixed model analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      DR\u2010JME patients demonstrated an altered gait pattern that included slower gait speed (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.018), reduced cadence (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.003), and smaller arm\u2010swing amplitude (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.011). The DR\u2010JME group showed higher motor\u2010evoked CSD in the postcentral gyri compared to responders (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.049) and both JME groups showed higher CSD in the superior frontal gyri compared to healthy controls (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.011). Moreover, higher CSD in the superior frontal gyri correlated with worse performance in dual\u2010task walking (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0&gt;\u00a0|\u20130.494|,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.008).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These alterations in gait and motor\u2010evoked responses in DRE\u2010JME patients reflect a more severe dysfunction of motor\u2010cognitive neural processing in frontocentral regions, leading to poorer gait performance. Further studies are needed to investigate the predictive value of altered gait and cortical motor processing as biomarkers for poor response to treatment in JME and other epilepsy syndromes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.2872","type":"journal-article","created":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T12:44:03Z","timestamp":1672922643000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Abnormal gait and motor cortical processing in drug\u2010resistant juvenile myoclonic epilepsy"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7370-5798","authenticated-orcid":false,"given":"Inbal","family":"Maidan","sequence":"first","affiliation":[{"name":"Brain Electrophysiology and Epilepsy Lab, Epilepsy Unit, Neurological Institute Tel Aviv Sourasky Medical Center  Tel Aviv Israel"},{"name":"Laboratory of Early Markers of Neurodegeneration, Center for the Study of Movement, Cognition and Mobility, Neurological Institute Tel Aviv Sourasky Medical Center  Tel Aviv Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"},{"name":"Sagol School of Neuroscience Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mor","family":"Yam","sequence":"additional","affiliation":[{"name":"Brain Electrophysiology and Epilepsy Lab, Epilepsy Unit, Neurological Institute Tel Aviv Sourasky Medical Center  Tel Aviv Israel"},{"name":"Sagol School of Neuroscience Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sigal","family":"Glatt","sequence":"additional","affiliation":[{"name":"Brain Electrophysiology and Epilepsy Lab, Epilepsy Unit, Neurological Institute Tel Aviv Sourasky Medical Center  Tel Aviv Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shai","family":"Nosatzki","sequence":"additional","affiliation":[{"name":"Brain Electrophysiology and Epilepsy Lab, Epilepsy Unit, Neurological Institute Tel Aviv Sourasky Medical Center  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilach","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Brain Electrophysiology and Epilepsy Lab, Epilepsy Unit, Neurological Institute Tel Aviv Sourasky Medical Center  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nir","family":"Giladi","sequence":"additional","affiliation":[{"name":"Brain Electrophysiology and Epilepsy Lab, Epilepsy Unit, Neurological Institute Tel Aviv Sourasky Medical Center  Tel Aviv Israel"},{"name":"Laboratory of Early Markers of Neurodegeneration, Center for the Study of Movement, Cognition and Mobility, Neurological Institute Tel Aviv Sourasky Medical Center  Tel Aviv 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