{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:06:35Z","timestamp":1793318795773,"version":"4.5.0"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T00:00:00Z","timestamp":1675728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["21Y11921500"],"award-info":[{"award-number":["21Y11921500"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["22Y11923200"],"award-info":[{"award-number":["22Y11923200"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["22ZR1453000"],"award-info":[{"award-number":["22ZR1453000"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>We aimed to evaluate the efficacy of electroacupuncture in relieving acute pain after total knee arthroplasty (TKA) and related mechanism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this randomized, single\u2010blind, and sham\u2010acupuncture controlled study. Forty patients with postoperative acute pain were recruited and randomly divided electroacupuncture group (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a020) and sham\u2010acupuncture group (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a020) from November 2020 to October 2021. All patients received electroacupuncture or sham\u2010acupuncture for 5 days after TKA. Their brain regions were scanned with resting\u2010state functional magnetic resonance imaging before and after intervention. Pain was scaled. Another 40 matched healthy controls underwent scanning once. The amplitude of low\u2010frequency fluctuation (ALFF) values was compared. Pearson's correlation analysis was utilized to explore the correlation of ALFF with clinical variables in patients after intervention.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with the HCs, patients with acute pain following TKA had significantly decreased ALFF value in right middle frontal gyrus, right supplementary motor area, bilateral precuneus, right calcarine fissure and surrounding cortex, and left triangular part of inferior frontal gyrus (false discovery rate corrected\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.05). Patients had higher ALFF value in bilateral precuneus, right cuneus, right angular gyrus, bilateral middle occipital gyrus, and left middle temporal gyrus after electroacupuncture (AlphaSim corrected\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.01). Correlation analysis revealed that the change (postoperative day 7 to postoperative day 3) of ALFF in bilateral precuneus were negatively correlated with the change of NRS scores (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0\u22120.706;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.002; 95%\n                      <jats:italic>CI<\/jats:italic>\n                      \u00a0=\u00a0\u22120.890 to \u22120.323) in EA group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The functional activities of related brain regions decreased in patients with acute pain after TKA. The enhancement of the functional activity of precuneus may be the neurobiological mechanism of electroacupuncture in treating pain following TKA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.2913","type":"journal-article","created":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T10:28:04Z","timestamp":1675765684000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Electroacupuncture alleviates pain after total knee arthroplasty through regulating neuroplasticity: A resting\u2010state functional magnetic resonance imaging study"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8829-3853","authenticated-orcid":false,"given":"Bingxin","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Rehabilitation centers The First Affiliated Hospital of Henan University of Chinese Medicine  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Acupuncture Tuina Institute Henan University of Chinese Medicine  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0451-7923","authenticated-orcid":false,"given":"Jie","family":"Ma","sequence":"additional","affiliation":[{"name":"Center of Rehabilitation Medicine Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiqi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Shanghai Guanghua Hospital of Integrative Chinese and Western Medicine  Shanghai 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