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The goal of this study was to characterize functional connectivity (FC) differences between subjects with temporomandibular disorders (TMD) and pain\u2010free controls during a visual functional magnetic resonance imaging (fMRI) task that included an unpleasant, strobing visual stimulus. We hypothesized the TMD cohort would exhibit maladaptations in brain networks consistent with multisensory hypersensitivities observed in TMD patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This pilot study included 16 subjects, 10 with TMD and 6 pain\u2010free controls. Clinical pain was characterized using self\u2010reported questionnaires. Visual task\u2010based fMRI data were collected on a 3T MR scanner and used to determine differences in FC via group independent component analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to controls, subjects with TMD exhibited abnormally <jats:italic>increased<\/jats:italic> FC between the default mode network and lateral prefrontal areas involved in attention and executive function, and <jats:italic>impaired<\/jats:italic> FC between the frontoparietal network and higher order visual processing areas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results indicate maladaptation of brain functional networks, likely due to deficits in multisensory integration, default mode network function, and visual attention\u00a0and\u00a0engendered by chronic pain mechanisms.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.2916","type":"journal-article","created":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T06:00:49Z","timestamp":1676527249000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Characterization of visual processing in temporomandibular disorders using functional magnetic resonance imaging"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7373-940X","authenticated-orcid":false,"given":"Daniel E.","family":"Harper","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Emory University School of Medicine  Atlanta Georgia USA"},{"name":"Chronic Pain and Fatigue Research Center, Department of Anesthesiology University of Michigan Medical School  Ann Arbor Michigan 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