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Repetitive transcranial magnetic stimulation (rTMS) has also been used for a long time as a substitution therapy for ET patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The main aim of this study was to evaluate the antitremor effect of 1\u2010Hz (low\u2010frequency) cerebellar rTMS and compare it to the use of propranolol in ET patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this single\u2010blinded, randomized, controlled pilot study, a total of 38 patients with ET were randomized into two groups. One group (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a020) received 1200 pulses of 1\u2010Hz rTMS at an intensity of 90% of the resting motor threshold to the bilateral cerebellar region for 10\u00a0days. Another group (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a018) received oral propranolol for 30 days. The initial dose was 30\u00a0mg\/day, which was increased to 60\u00a0mg\/day after 5\u00a0days, then to 90\u00a0mg\/day on the 11th day, and continued thereafter for 20\u00a0days. The Fahn\u2013Tolosa\u2013Marin (FTM) clinical scale was assessed at baseline and at days 5, 10, and 30 to evaluate tremor severity, specific motor tasks, and functional disability.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Low\u2010frequency rTMS of the cerebellum significantly improved tremor severity, specific motor tasks (writing, spiral drawing, and pouring), and FTM total scores on days 10 and 30. Nevertheless, we found no significant difference in functional disability at any point in time (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&gt;\u00a0.05). There were no statistically significant differences in FTM Part A, Part B, Part C scores and total scores of patients in propranolol group on days 5 and 10 compared with before treatment (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&gt;\u00a0.05). However, FTM total scores and FTM Part A, Part B, and Part C scores were significantly improved for patients when the dose of propranolol was 90\u00a0mg\/day on day 30. Our study showed that there was no statistically significant difference in the total FTM scores and FTM Part A, Part B, and Part C scores between rTMS and propranolol on days 5, 10, and 30 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&gt;\u00a0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We conclude that both cerebellar low\u2010frequency rTMS and propranolol could be effective treatment options for patients with ET, but it is not clear which method is more effective.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.2926","type":"journal-article","created":{"date-parts":[[2023,2,18]],"date-time":"2023-02-18T12:58:58Z","timestamp":1676725138000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Cerebellar repetitive 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