{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T12:16:50Z","timestamp":1783426610379,"version":"3.54.6"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T00:00:00Z","timestamp":1678060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study aimed to explore circular RNA (circRNA) hsa_circ_0000690 as a potential biomarker for diagnosis and prognosis of intracranial aneurysm (IA) and its relationship with clinical factors and complications of IA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material\/methods<\/jats:title>\n                    <jats:p>216 IA patients admitted to the neurosurgery department of our hospital from January 2019 to December 2020 were selected as the experimental group, and 186 healthy volunteers were selected as the control group. The expression of hsa_circ_0000690 in peripheral blood was detected by quantitative real\u2010time PCR, and its diagnostic value was assessed by receiver operating characteristic curve. Relationship between hsa_circ_0000690 and clinical factors of IA was assessed by chi\u2010square test. Nonparametric test was used in univariate analysis, and regression analysis was used in multivariate analysis. Multivariate Cox proportional hazards regression analysis was used to analyze the survival time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CircRNA hsa_circ_0000690 of IA patients was relatively lower than that in the control group (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.001). The AUC of hsa_circ_0000690 was 0.752, the specificity was 0.780, and sensitivity was 0.620, with diagnostic threshold of 0.0449. In addition, hsa_circ_0000690 expression was correlated with Glasgow Coma Scale, the volume of subarachnoid hemorrhage, modified Fisher scale, Hunt\u2013Hess levels and surgical type. For hydrocephalus and delayed cerebral ischemia, hsa_circ_0000690 was significant in univariate analysis, but nonsignificant in multivariate analysis. For prognosis, hsa_circ_0000690 was significantly associated with modified Rankin Scales after surgery for 3 months, but not associated with survival time.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The expression of hsa_circ_0000690 can act as a diagnostic marker for IA and predict the prognosis of 3 months after operation and is closely related to the volume of hemorrhage.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.2929","type":"journal-article","created":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T23:39:22Z","timestamp":1678145962000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Circular RNA hsa_circ_0000690 as a potential biomarker for diagnosis and prognosis of intracranial aneurysm: Closely relating to the volume of hemorrhage"],"prefix":"10.1002","volume":"13","author":[{"given":"Yanming","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Longyan First Affiliated Hospital of Fujian Medical University  Longyan Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Cao","sequence":"additional","affiliation":[{"name":"Clinical Laboratory Longyan First Affiliated Hospital of Fujian Medical University  Longyan Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolong","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Longyan First Affiliated Hospital of Fujian Medical University  Longyan Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celin","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Longyan First Affiliated Hospital of Fujian Medical University  Longyan Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0197-8433","authenticated-orcid":false,"given":"Shuanglin","family":"Que","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Longyan First Affiliated Hospital of Fujian Medical University  Longyan Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2018.4165"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2021.1899674"},{"issue":"53","key":"e_1_2_11_4_1","first-page":"2117","article-title":"Een graadmeter van het bewustzijn; de Glasgow \u201ccoma\u201d\u2010schaal [A scoring device for the level of consciousness: The Glasgow \u201ccoma\u201d scale]","volume":"121","author":"Avezaat C. 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