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Both the virus and its vaccine, like other members of the\n                    <jats:italic>Orthopoxvirus<\/jats:italic>\n                    family, were always expected to have neuropsychiatric consequences. Several neurological complications have been reported with MPX and its vaccines that include but not limited to headaches, myalgia, encephalitis, and coma. Psychiatric complications like anxiety and depression have also been reported; however, we lack evidence to present a direct causality. We conducted a literature review to compile recent evidence on neuropsychiatric manifestations and underline the importance of evolving aspects and complications of MPX. We advocate for better reporting of cases and adverse events, to enhance our understanding of the disease, aiding physicians to make more informed decisions, thus facilitating timely diagnosis and treatment.\n                  <\/jats:p>","DOI":"10.1002\/brb3.2934","type":"journal-article","created":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T11:44:58Z","timestamp":1677498298000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Neuropsychiatric manifestations of monkeypox: A clinically oriented comprehensive review"],"prefix":"10.1002","volume":"13","author":[{"given":"Yashendra","family":"Sethi","sequence":"first","affiliation":[{"name":"Department of Medicine Government Doon Medical College  Dehradun India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pratik","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Medicine Lokmanya Tilak Municipal Medical College  Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamsa","family":"Murli","sequence":"additional","affiliation":[{"name":"Department of Medicine Lokmanya Tilak Municipal Medical College  Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Summaiya","family":"Waheed","sequence":"additional","affiliation":[{"name":"Department of Medicine Dow Medical College, Dow University Of Health Sciences  Karachi Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sajeda Ghassan","family":"Matar","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Applied Science Private University  Amman Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Baklola","sequence":"additional","affiliation":[{"name":"Faculty of medicine Mansoura University  Mansoura Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitesh","family":"Chopra","sequence":"additional","affiliation":[{"name":"Chitkara College of Pharmacy Chitkara University  Punjab India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Talha Bin","family":"Emran","sequence":"additional","affiliation":[{"name":"Department of Pharmacy BGC Trust University Bangladesh  Chittagong Bangladesh"},{"name":"Department of Pharmacy, Faculty of Allied Health Sciences Daffodil International University  Dhaka Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9727-8620","authenticated-orcid":false,"given":"Elfatih A.","family":"Hasabo","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Khartoum  Khartoum Sudan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,2,27]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.nrl.0000138998.11209.88"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473\u20103099(22)00228\u20106"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2020.11.012"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000101821.61387.a5"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100714.2007.00586.x"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2022.101644"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2005.73.428"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000063319.64515.6B"},{"issue":"1","key":"e_1_2_15_10_1","first-page":"17","article-title":"[Simian smallpox (or monkey smallpox): Study of 8 cases observed at Impfondo Hospital in Republic of Congo]","volume":"100","author":"Boumandouki P.","year":"2007","journal-title":"Bulletin de La Societe de Pathologie Exotique"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.05.057"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.27913"},{"issue":"2","key":"e_1_2_15_13_1","first-page":"165","article-title":"Human monkeypox, 1970\u201379","volume":"58","author":"Breman J. 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