{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:04:31Z","timestamp":1772118271732,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,3,19]],"date-time":"2023-03-19T00:00:00Z","timestamp":1679184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160195"],"award-info":[{"award-number":["82160195"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Previous studies have indicated that pain\u2010related diseases can result in significant functional alterations in the brain. However, differences in spontaneous brain activity in toothache (TA) patients remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate altered spontaneous brain activity in patients with TA and its underlying mechanisms using the resting\u2010state functional magnetic resonance imaging\u2013fractional amplitude of low\u2010frequency fluctuation (rsfMRI\u2013fALFF) technique.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twelve patients with TA and 12 non\u2010toothache controls (NTCs) (matched for sex, age, and level of education) were enrolled. Spontaneous cerebral activity variations were investigated using the rsfMRI\u2013fALFF technique in all individuals. The mean fALFF values of the TA patients and NTCs were classified using receiver operating characteristic (ROC) curves. The correlations between fALFF signals of distinct brain regions and clinical manifestations of TA patients were evaluated using Pearson's correlation analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      TA patients showed lower fALFF values in the left superior frontal gyrus, medial; right superior frontal gyrus, dorsolateral; and left median cingulate and paracingulate gyri (LDCG) than the NTCs. Moreover, ROC curve analysis indicated that the area under the curve of each cerebral region studied had high accuracy. Besides, in the TA group, the visual analog scale score was negatively correlated with fALFF signal values of the LDCG (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0.962,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Abnormal spontaneous activity was detected in numerous brain regions in patients with TA, which may be valuable for understanding the brain processing mechanism underlying TA. These regional changes in brain activity may serve as effective clinical indicators of TA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.2937","type":"journal-article","created":{"date-parts":[[2023,3,19]],"date-time":"2023-03-19T15:40:37Z","timestamp":1679240437000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Fractional amplitude of low\u2010frequency fluctuation changes of specific cerebral regions in patients with toothache: A functional magnetic resonance imaging study"],"prefix":"10.1002","volume":"13","author":[{"given":"Jun","family":"Yang","sequence":"first","affiliation":[{"name":"The Affiliated Stomatological Hospital of Nanchang University The Key Laboratory of Oral Biomedicine  Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7825-8026","authenticated-orcid":false,"given":"Wan\u2010Xin","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology The First Affiliated Hospital of Nanchang University, Jiangxi Branch of National Clinical Research Center for Ocular Disease  Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology The First Affiliated Hospital of Nanchang University, Jiangxi Branch of National Clinical Research Center for Ocular Disease  Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2681-7655","authenticated-orcid":false,"given":"Min","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology The First Affiliated Hospital of Nanchang University, Jiangxi Branch of National Clinical Research Center for Ocular Disease  Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu\u2010Lin","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences The Chinese University of Hong Kong  Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3539-9050","authenticated-orcid":false,"given":"Ping","family":"Ying","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology The First Affiliated Hospital of Nanchang University, Jiangxi Branch of National Clinical Research Center for Ocular Disease  Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Ling","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology The First Affiliated Hospital of Nanchang University, Jiangxi Branch of National Clinical Research Center for Ocular Disease  Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4735-6413","authenticated-orcid":false,"given":"Jie","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology The First Affiliated Hospital of Nanchang University, Jiangxi Branch of National Clinical Research Center for Ocular Disease  Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology The First Affiliated Hospital of Nanchang University, Jiangxi Branch of National Clinical Research Center for Ocular Disease  Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Massachusetts Eye and Ear Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0210-5482","authenticated-orcid":false,"given":"Ting","family":"Su","sequence":"additional","affiliation":[{"name":"School of optometry and vision science Cardiff University  Cardiff UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1571-2433","authenticated-orcid":false,"given":"Yi","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences The Chinese University of Hong Kong  Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,3,19]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"StatPearls","author":"Al\u2010Chalabi 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