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In pediatric patients with OCD, neuroimaging research implicates altered neural mechanisms for error\u2010processing, but whether abnormal brain response occurs with subclinical OCS remains poorly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using functional magnetic resonance imaging (fMRI), 113 youth (8\u201318 years; 45 female) from a community sample were scanned during an error\u2010eliciting Go\/No\u2010Go task. OCS were assessed dimensionally using the obsessive\u2013compulsive subscale of the Child Behavior Checklist. The association between OCS scores and error\u2010related brain activity was examined at the whole\u2010brain level.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Lower OCS scores associated with stronger response to errors in dorsal anterior cingulate cortex (dACC), caudate, putamen, thalamus, and occipital cortex. Additionally, lower OCS related to higher capacity for inhibitory control, as indexed by greater accuracy on No\u2010Go trials during fMRI scanning. The relationship between lower OCS and better accuracy on No\u2010Go trials was mediated by greater error\u2010related dACC activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The inverse relationship between OCS and error\u2010related activity in the dACC and extended cortical\u2013striatal\u2013thalamic circuitry may index an adaptive process by which subclinical OCS are minimized in youth. Further, these results identify an observable pattern of brain activity that tracks with subclinical OCS severity. Understanding the link between neural networks for error processing and the normal to abnormal range of OCS may pave the way for brain\u2010based strategies to identify children who are more likely to develop OCD and enable the targeting of preventive strategies to reduce risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.2941","type":"journal-article","created":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T01:49:23Z","timestamp":1678844963000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Error\u2010related brain activity associated with obsessive\u2013compulsive symptoms in youth"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6944-1208","authenticated-orcid":false,"given":"Hannah","family":"Becker","sequence":"first","affiliation":[{"name":"Department of Psychology, University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanni","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory L.","family":"Hanna","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Bilek","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie Russman","family":"Block","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jillian E.","family":"Hardee","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Michigan  Ann Arbor Michigan USA"},{"name":"Addiction Research Center University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary M.","family":"Heitzeg","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Michigan  Ann Arbor Michigan USA"},{"name":"Addiction Research Center University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Pagliaccio","sequence":"additional","affiliation":[{"name":"New York State Psychiatric Institute Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Marsh","sequence":"additional","affiliation":[{"name":"New York State Psychiatric Institute Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate D.","family":"Fitzgerald","sequence":"additional","affiliation":[{"name":"New York State Psychiatric Institute Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2005.09.011"},{"key":"e_1_2_9_3_1","first-page":"429","volume-title":"The use of psychological testing for treatment planning and outcomes assessment","author":"Achenbach T. 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