{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T21:59:57Z","timestamp":1783029597899,"version":"3.54.6"},"reference-count":56,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T00:00:00Z","timestamp":1678838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Childhood trauma has been associated with adult psychosocial outcomes linked to social exclusion. However, the strength of these associations in the general population is unknown. The emergence of the UK Biobank, with rich phenotypic characterization of the adult population, affords the exploration of the childhood determinants of adult psychopathology with greater statistical power. The current study aims to explore (1) the associations between childhood trauma and social exclusion in adulthood and (2) the role that self\u2010reported loneliness and symptoms of distress play in the associations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study was an analysis of 87,545 participants (mean [\u00b1\u00a0SD] age\u00a0=\u00a055.68 [7.78], 55.0% female, 97.4% White) enrolled in the UK Biobank. Childhood trauma was determined by the five\u2010item Childhood Trauma Screener. Current loneliness and symptoms of anxiety (Generalized Anxiety Disorder Scale\u20107) and depression (Patient Health Questionnaire\u20109) were also entered in analyses. Outcomes were \u201climited social participation,\u201d \u201carea deprivation,\u201d \u201cindividual deprivation,\u201d and \u201csocial exclusion\u201d from a previously determined dimensional measure of social exclusion in the UK Biobank.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Hierarchical multiple regression models indicated small associations between childhood trauma and social exclusion outcomes, explaining between 1.5% and 5.0% of the variance. Associations weakened but remained significant when loneliness, anxiety, and depression were entered in the models; however, anxiety symptoms demonstrated a negative association with \u201cindividual deprivation\u201d and \u201csocial exclusion\u201d in the final models. Depression was most strongly associated with \u201cindividual deprivation,\u201d \u201carea deprivation,\u201d and \u201csocial exclusion\u201d followed by childhood trauma. Loneliness was most strongly associated with \u201climited social participation.\u201d<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Experiences of childhood trauma can increase the propensity for adulthood social exclusion. Loneliness and symptoms of depression attenuate but do not eliminate these associations. Anxiety symptoms have a potentially protective effect on the development of \u201cindividual deprivation.\u201d Findings add to the growing body of literature advocating for trauma\u2010informed approaches in a variety of settings to help ameliorate the effects of childhood trauma on adult psychosocial outcomes. Further research, however, is required.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.2959","type":"journal-article","created":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T01:44:50Z","timestamp":1678931090000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["The associations among childhood trauma, loneliness, mental health symptoms, and indicators of social exclusion in adulthood: A UK Biobank study"],"prefix":"10.1002","volume":"13","author":[{"given":"Sarah F.","family":"Allen","sequence":"first","affiliation":[{"name":"Department of Psychology Northumbria University  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Gilbody","sequence":"additional","affiliation":[{"name":"Department of Health Sciences University of York  York UK"},{"name":"Hull York Medical School University of York  York UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Atkin","sequence":"additional","affiliation":[{"name":"Department of Health Sciences University of York  York UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina M.","family":"van der Feltz\u2010Cornelis","sequence":"additional","affiliation":[{"name":"Department of Health Sciences University of York  York UK"},{"name":"Hull York Medical School University of York  York UK"},{"name":"York Biomedical Research Institute University of York  York UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,15]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2020.06.028"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-005-0624-4"},{"key":"e_1_2_11_4_1","unstructured":"Bauermeister S. &Gallacher J.(2018).The effect of childhood adversity on adult behavioural psychological cognitive and health outcomes. 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