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Data were collected with the use of the short form brief pain inventory (<jats:styled-content style=\"fixed-case\">BPI<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Pain was reported in 78% of <jats:styled-content style=\"fixed-case\">ALS<\/jats:styled-content> patients,79% of <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>2 patients, and 54% of controls (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). More <jats:styled-content style=\"fixed-case\">ALS<\/jats:styled-content> patients than controls reported moderate to severe pain (42% vs. 20%). Pain in <jats:styled-content style=\"fixed-case\">ALS<\/jats:styled-content> patients interfered significantly more with daily activities than in controls (median pain interference score: 3.0 vs. 1.2, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05), especially enjoyment of life (5.0 vs. 1.0) and mood (3.0 vs. 1.0). There was no correlation between the duration of the disease and the severity of pain. Movement\u2010induced cramps were reported in 63% of <jats:styled-content style=\"fixed-case\">ALS<\/jats:styled-content> patients, mostly in the distal extremities. There was no difference in the duration of <jats:styled-content style=\"fixed-case\">ALS<\/jats:styled-content> disease between patients reporting cramps and those who did not.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Our study showed that pain was a relatively frequent symptom which had an important impact on the quality of life. Pain that requires treatment can occur at every stage of <jats:styled-content style=\"fixed-case\">ALS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.296","type":"journal-article","created":{"date-parts":[[2015,1,22]],"date-time":"2015-01-22T00:15:42Z","timestamp":1421885742000},"source":"Crossref","is-referenced-by-count":67,"title":["Characteristics of pain in amyotrophic lateral sclerosis"],"prefix":"10.1002","volume":"5","author":[{"given":"Frank","family":"Hanisch","sequence":"first","affiliation":[{"name":"Department of Neurology Martin\u2010Luther\u2010University Halle\u2010Wittenberg Ernst\u2010Grube\u2010Str. 40 Halle (Saale) D\u201006120 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anika","family":"Skudlarek","sequence":"additional","affiliation":[{"name":"Department of Neurology Martin\u2010Luther\u2010University Halle\u2010Wittenberg Ernst\u2010Grube\u2010Str. 40 Halle (Saale) D\u201006120 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janine","family":"Berndt","sequence":"additional","affiliation":[{"name":"Department of Neurology Martin\u2010Luther\u2010University Halle\u2010Wittenberg Ernst\u2010Grube\u2010Str. 40 Halle (Saale) D\u201006120 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malte E.","family":"Kornhuber","sequence":"additional","affiliation":[{"name":"Department of Neurology Martin\u2010Luther\u2010University Halle\u2010Wittenberg Ernst\u2010Grube\u2010Str. 40 Halle (Saale) D\u201006120 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,1,21]]},"reference":[{"issue":"4","key":"e_1_2_7_2_1","first-page":"CD004157","article-title":"Treatment for cramps in amyotrophic lateral sclerosis\/motor neuron disease","author":"Baldinger R.","year":"2012","journal-title":"Cochrane Database Syst. 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