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However, few studies have evaluated the influence of interindividual corticomotor responses to musculoskeletal pain. Existing research in this area has also been limited largely to the upper limb. This is a pertinent point, given the functional and neurophysiological differences between upper and lower limb muscles, as well as the fact that most acute sporting injuries occur in the lower limb. Accordingly, this study explored the variability of corticomotor responses to experimentally\u2010induced sustained hamstring pain and whether specific patterns of corticomotor reorganization were associated with poorer outcomes (mechanical sensitivity, pain, or functional limitation).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Thirty\u2010six healthy individuals participated. Following random allocation on Day 0, the experimental group performed an eccentric exercise protocol of the right hamstring muscles to induce delayed onset muscle soreness. The control group performed repetition\u2010matched concentric exercise that did not induce soreness. Measures of mechanical sensitivity, pain, function, and corticomotor organization were collected at baseline and on Day 2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results and conclusions<\/jats:title>\n                    <jats:p>Corticomotor responses to sustained hamstring pain were variable. Individuals who developed corticomotor facilitation in response to hamstring pain experienced greater mechanical sensitivity than those who developed corticomotor depression. These novel data could have implications for rehabilitation following lower limb pain or injury.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.2996","type":"journal-article","created":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T03:30:30Z","timestamp":1681183830000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Investigating interindividual variability in corticomotor reorganization during sustained hamstring pain: A randomized experimental study"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9499-1703","authenticated-orcid":false,"given":"Rocco","family":"Cavaleri","sequence":"first","affiliation":[{"name":"Brain Stimulation and Rehabilitation (BrainStAR) Lab, School of Health Sciences Western Sydney University  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jawwad","family":"Imam","sequence":"additional","affiliation":[{"name":"Brain Stimulation and Rehabilitation (BrainStAR) Lab, School of Health Sciences Western Sydney University  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ebonie","family":"Rio","sequence":"additional","affiliation":[{"name":"School of Allied Health La Trobe University  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Moukhaiber","sequence":"additional","affiliation":[{"name":"Brain Stimulation and Rehabilitation (BrainStAR) Lab, School of Health Sciences Western Sydney University  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Thomson","sequence":"additional","affiliation":[{"name":"Brain Stimulation and Rehabilitation (BrainStAR) Lab, School of Health Sciences Western Sydney University  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ariane","family":"Suhood","sequence":"additional","affiliation":[{"name":"Brain Stimulation and Rehabilitation (BrainStAR) Lab, School of Health Sciences Western Sydney University  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon J.","family":"Summers","sequence":"additional","affiliation":[{"name":"Brain Stimulation and Rehabilitation (BrainStAR) Lab, School of Health Sciences Western Sydney University  Sydney New South Wales Australia"},{"name":"School of Biomedical Sciences Queensland University of Technology  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,4,11]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"Encyclopedia of research design","author":"Abdi H.","year":"2010"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.1156"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-198412000-00002"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0160866"},{"issue":"4","key":"e_1_2_10_6_1","first-page":"371","article-title":"The lower extremity functional scale (LEFS): Scale development, measurement properties, and clinical application. 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