{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T04:19:23Z","timestamp":1779250763506,"version":"3.51.4"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,4,23]],"date-time":"2023-04-23T00:00:00Z","timestamp":1682208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Subtle cognitive decline (SCD) is considered the early stage of Alzheimer's disease (AD) and is of great clinical significance for the prevention and treatment of AD. The ankle\u2010brachial index (ABI) has been reported to be associated with cognitive impairment; however, there are few studies on the relationship between ABI and SCD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From August 2019 to April 2021, subjects were recruited to participate in a cognitive function test at the Shanghai Sixth People's Hospital. Based on the test results, 217 patients with SCD were selected as the experimental group and 259 patients with normal cognitive function were selected as the control group. The data of the two groups were compared, and the correlation between the ABI and cognitive decline was analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were significant differences in age, sex, smoking status, hypertension, diabetes, triglycerides, serum creatinine, and ABI (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.05)between the two groups. Logistic regression analysis showed that age, hypertension, diabetes, and ABI influenced cognitive decline(\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.05). After correcting for other factors, ABI was independently related to cognitive decline. Pearson's correlation analysis showed that a low ABI (&lt;0.9) had a significant effect on memory and visual space of the cognitive domain (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0. 05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ABI is significantly associated with SCD and may be a critical tool to predict early cognitive decline.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.3019","type":"journal-article","created":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T02:04:58Z","timestamp":1682301898000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Correlation between ankle\u2010brachial index and subtle cognitive decline"],"prefix":"10.1002","volume":"13","author":[{"given":"Hui\u2010Feng","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Gerontology Shanghai Jiao Tong University Affiliated Sixth People's Hospital  Shanghai P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Wu","sequence":"additional","affiliation":[{"name":"The International Peace Maternity and Child Health Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo\u2010Xiang","family":"Fu","sequence":"additional","affiliation":[{"name":"Shanghai Tenth People's Hospital Tongji University  Shanghai P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gerontology Shanghai Jiao Tong University Affiliated Sixth People's Hospital  Shanghai P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie\u2010Hua","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Gerontology Shanghai Jiao Tong University Affiliated Sixth People's Hospital  Shanghai P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,4,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e318276fbcb"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e318232a379"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/475S1a"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2007.04.381"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.559740"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2022.06.002"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jon.13055"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199202063260605"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003319717736608"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010150128"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(05)67889\u20100"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(18)30499\u2010X"},{"key":"e_1_2_6_14_1","first-page":"13","article-title":"Reliability and validity of auditory verbal learning test on Chinese elderly patients","volume":"15","author":"Guo Q.","year":"2001","journal-title":"Journal of Chinese Mental Health"},{"key":"e_1_2_6_15_1","first-page":"701","article-title":"Application of Stroop color\u2010word test on Chinese elderly patients with mild cognitive impairment and mild Alzheimer's dementia","volume":"4","author":"Guo Q.","year":"2005","journal-title":"Chinese Journal of Neuromedicine"},{"key":"e_1_2_6_16_1","first-page":"81","article-title":"Boston naming test using by Chinese elderly, patient with mild cognitive impairment and Alzheimer's dementia","volume":"20","author":"Guo Q.","year":"2006","journal-title":"Journal of Chinese Mental Health"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.23.1.56"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2006.03.011"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000357372"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.04.034"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.018"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(12)70291\u20100"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(09)70299\u20106"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.01.001.Epub"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010017\u20101717\u20107"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semvascsurg.2014.01.002"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/msj.21347"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/0891988711422528"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/547153a"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12336"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000168052.00426.65"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2019.09.074"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2012.11.007"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/09602011.2014.915855"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u20102012\u2010120757"},{"issue":"4","key":"e_1_2_6_36_1","first-page":"30","article-title":"Dementia: a systematic approach to identifying reversible causes","volume":"41","author":"Reisberg B.","year":"1986","journal-title":"Geriatrics"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.139.9.1136"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102261\u20108\u201026"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2015.80"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3002609"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.003"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2018.02.016"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000008838"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2011.08.014"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.1601"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010141563"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0057333"},{"key":"e_1_2_6_48_1","first-page":"241","article-title":"Category verbal fluency test in identification and differential diagnosis of dementia","volume":"3","author":"Zhao Q.","year":"2007","journal-title":"Chinese Journal of Clinical Psychology"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.3019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T21:59:37Z","timestamp":1692482377000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.3019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,23]]},"references-count":47,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1002\/brb3.3019"],"URL":"https:\/\/doi.org\/10.1002\/brb3.3019","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/BRB3.3019\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3019\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3019\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3019\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3019\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3019\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3019\/v2\/review1","asserted-by":"object"}]},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,23]]},"assertion":[{"value":"2022-01-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e3019"}}