{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:01:57Z","timestamp":1772118117462,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T00:00:00Z","timestamp":1689638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005273","name":"Natural Science Foundation of Yunnan Province","doi-asserted-by":"publisher","award":["202001BC070001"],"award-info":[{"award-number":["202001BC070001"]}],"id":[{"id":"10.13039\/501100005273","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005273","name":"Natural Science Foundation of Yunnan Province","doi-asserted-by":"publisher","award":["202102AA100053"],"award-info":[{"award-number":["202102AA100053"]}],"id":[{"id":"10.13039\/501100005273","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62176044"],"award-info":[{"award-number":["62176044"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31700910"],"award-info":[{"award-number":["31700910"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81941014"],"award-info":[{"award-number":["81941014"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771387"],"award-info":[{"award-number":["81771387"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31800901"],"award-info":[{"award-number":["31800901"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Anxious behaviors often occur in individuals who have experienced early adversity. Anxious behaviors can bring many hazards, such as social withdrawal, eating disorders, negative self\u2010efficacy, self\u2010injurious thoughts and behaviors, anxiety disorders, and even depression. Abnormal behavior are is closely related to changes in corresponding circuit functions in the brain. This study investigated the relationship between brain circuits and anxious behaviors in maternal\u2010deprived rhesus monkey animal model, which mimic early adversity in human.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010five rhesus monkeys (\n                      <jats:italic>Macaca mulatta<\/jats:italic>\n                      ) were grouped by two different rearing conditions: 11 normal control and mother\u2010reared (MR) monkeys and 14 maternally deprived and peer\u2010reared (MD) monkeys. After obtaining images of the brain areas with significant differences in maternal separation and normal control macaque function, the relationship between functional junction intensity and stereotypical behaviors was determined by correlation analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The correlation analysis revealed that stereotypical behaviors were negatively correlated with the coupling between the left lateral amygdala subregion and the left inferior frontal gyrus in both MD and MR macaques.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study suggests that early adversity\u2010induced anxious behaviors are associated with changes in the strength of the amygdala\u2013prefrontal connection. The normalization of the regions involved in the functional connection might reverse the behavioral abnormality. It provides a solid foundation for effective intervention in human early adversity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance Statement<\/jats:title>\n                    <jats:p>This study suggests that early adversity\u2010induced anxious behaviors are associated with changes in the strength of the amygdala\u2013prefrontal connection. The higher the amygdala\u2013prefrontal connection strength, the less stereotyped behaviors exhibited by monkeys experiencing early adversity. Thus, in the future, changing the strength of the amygdala\u2013prefrontal connection may reverse the behavioral abnormalities of individuals who experience early adversity. This study provides a solid foundation for effective intervention in humans' early adversity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.3027","type":"journal-article","created":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T01:19:42Z","timestamp":1689729582000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Abnormality of anxious behaviors and functional connectivity between the amygdala and the frontal lobe in maternally deprived monkeys"],"prefix":"10.1002","volume":"13","author":[{"given":"Xiao\u2010Li","family":"Feng","sequence":"first","affiliation":[{"name":"Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences &amp; Yunnan Province, Kunming Institute of Zoology Chinese Academy of Sciences Kunming Yunnan China"},{"name":"Department of Physiology Faculty of Basic Medical Science Kunming Medical University Kunming Yunnan China"},{"name":"Institute of Neuroscience Kunming Medical University Kunming Yunnan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiao\u2010Jian","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Primate Biomedical Research Institute of Primate Translational Medicine Kunming University of Science and Technology Kunming China"},{"name":"Yunnan Key Laboratory of Primate Biomedical Research Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences &amp; Yunnan Province, Kunming Institute of Zoology Chinese Academy of Sciences Kunming Yunnan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Feng","family":"Ren","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences &amp; Yunnan Province, Kunming Institute of Zoology Chinese Academy of Sciences Kunming Yunnan China"},{"name":"Kunming College of Life Science University of Chinese Academy of Sciences Kunming Yunnan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3307-560X","authenticated-orcid":false,"given":"Hui","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Physiology Faculty of Basic Medical Science Kunming Medical University Kunming Yunnan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si\u2010Yu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Physiology Faculty of Basic Medical Science Kunming Medical University Kunming Yunnan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences Kunming Medical University Kunming Yunnan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng\u2010Hai","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences Kunming Medical University Kunming Yunnan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Wang","sequence":"additional","affiliation":[{"name":"National Resource Center for Non\u2010Human Primates, Kunming Primate Research Center, and National Research Facility for Phenotypic &amp; Genetic Analysis of Model Animals (Primate Facility), Kunming Institute of Zoology Chinese Academy of Sciences Kunming Yunnan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng\u2010Fei","family":"Hu","sequence":"additional","affiliation":[{"name":"National Resource Center for Non\u2010Human Primates, Kunming Primate Research Center, and National Research Facility for Phenotypic &amp; Genetic Analysis of Model Animals (Primate Facility), Kunming Institute of Zoology Chinese Academy of Sciences Kunming Yunnan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin\u2010Tian","family":"Hu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences &amp; Yunnan Province, Kunming Institute of Zoology Chinese Academy of Sciences Kunming Yunnan China"},{"name":"National Resource Center for Non\u2010Human Primates, Kunming Primate Research Center, and National Research Facility for Phenotypic &amp; Genetic Analysis of Model Animals (Primate Facility), Kunming Institute of Zoology Chinese Academy of Sciences Kunming Yunnan China"},{"name":"Center for Excellence in Brain Science Chinese Academy of Sciences Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian\u2010Zi","family":"Jiang","sequence":"additional","affiliation":[{"name":"Brainnetome Center and National Laboratory of Pattern Recognition Institute of Automation Chinese Academy of Sciences Beijing China"},{"name":"Research Center for Augmented Intelligence Zhejiang Laboratory Hangzhou China"},{"name":"Center for Excellence in Brain Science Institute of Automation Chinese Academy of Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,7,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2014.11.001"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2021.105272"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.09.018"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.applanim.2018.07.002"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0128608"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2017.08.023"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.11813\/j.issn.0254\u20105853.2014.3.174"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2020.09.058"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978\u20100\u2010444\u201064150\u20102.00005\u20108"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3758\/CABN.10.1.141"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1010943108"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.03.038"},{"key":"e_1_2_11_14_1","doi-asserted-by":"crossref","unstructured":"Ge F. Jiang J. Wang Y. Wan M. &Zhang W.(2021).Mapping the presence of anxiety symptoms in adults with major depressive disorder.Frontiers in Psychiatry 12 595418.https:\/\/doi.org\/10.3389\/fpsyt.2021.595418","DOI":"10.3389\/fpsyt.2021.595418"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1307893110"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2017.07.004"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2014.03.030"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0072332"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nst021"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2012.00052"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.10.020"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2013.11.012"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/1362361319868907"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.12825"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.07.039"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2012.00345"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1301.021"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2011.04.025"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2021.673162"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2012.05.036"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2020.07.012"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2015.04.007"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469\u20107610.2010.02271.x"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1258\/jrsm.2011.110222"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2004.05.011"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0499\u201006.2006"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2008.150"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2019.109726"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2014.10.001"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2006.07.004"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/jir.12558"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhv103"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2020.02.015"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2018.11.025"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nsu008"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.07.045"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2007.03.009"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.06.041"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.3027","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T02:42:25Z","timestamp":1694572945000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.3027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,18]]},"references-count":47,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1002\/brb3.3027"],"URL":"https:\/\/doi.org\/10.1002\/brb3.3027","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/BRB3.3027\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3027\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3027\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3027\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3027\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3027\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3027\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3027\/v1\/decision1","asserted-by":"object"}]},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,18]]},"assertion":[{"value":"2022-07-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e3027"}}