{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T11:10:55Z","timestamp":1791544255930,"version":"4.3.4"},"reference-count":64,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T00:00:00Z","timestamp":1683158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Exercise preconditioning (EP) is essential for preventing ischemic stroke. Recent studies have shown that EP exerts neuroprotective effects in the cerebral ischemia\u2010reperfusion injury model. Nonetheless, there have been few reports on the relationship between EP and the Th17\/Treg balance. Moreover, it is unclear whether the JAK2\/STAT3 pathway is responsible for the neuroprotective effect of EP. Therefore, we aimed to explore the impact of EP, other than the anti\u2010inflammatory and antiapoptotic functions, on the Th17\/Treg balance via the JAK2\/STAT3 pathway in a middle cerebral artery occlusion (MCAO)\u2010induced model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifty rats were randomly allocated into five groups, including the sham group (\n                      <jats:italic>n<\/jats:italic>\n                      = 10), EP+sham group (\n                      <jats:italic>n<\/jats:italic>\n                      = 10), MCAO group (\n                      <jats:italic>n<\/jats:italic>\n                      = 10), EP+MCAO group (\n                      <jats:italic>n<\/jats:italic>\n                      = 10), and EP+MCAO+JAK2\/STAT3 pathway agonist (coumermycin A1, CA1) group (\n                      <jats:italic>n<\/jats:italic>\n                      = 10). The results indicated that EP alleviated neurological deficits, reduced infarct volume, and ameliorated neuronal apoptosis induced by MCAO. Additionally, the MCAO\u2010induced Th17\/Treg imbalance could be rectified by EP. The decreased levels of IL\u201010 and Foxp3 and increased IL\u201017 and ROR\u03b1 in the MCAO group were reversed by EP treatment. Regarding inflammation, EP reduced the concentrations of IL\u20106 and IL\u201017 and elevated those of IL\u201010 and TGF\u2011\u03b2. The neuroprotective effects of EP were accompanied by decreased phosphorylation of JAK2 and STAT3. Furthermore, CA1 pretreatment diminished all the beneficial effects of EP partially.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings suggest that EP contributes to attenuating neuronal apoptosis, Th17\/Treg imbalance, and inflammation induced by MCAO via inhibiting the JAK2\/STAT3 pathway, indicating its therapeutic potential in ischemic stroke.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.3030","type":"journal-article","created":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T02:45:43Z","timestamp":1683254743000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Exercise preconditioning attenuates cerebral ischemia\u2010induced neuronal apoptosis, Th17\/Treg imbalance, and inflammation in rats by inhibiting the JAK2\/STAT3 pathway"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3906-4082","authenticated-orcid":false,"given":"Yuan","family":"Shan","sequence":"first","affiliation":[{"name":"Department of Neurology Shaanxi Provincial People's Hospital  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology Shaanxi Provincial People's Hospital  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingying","family":"Sun","sequence":"additional","affiliation":[{"name":"Central Research Laboratory Shaanxi Provincial People's Hospital  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sha","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Neurology Shaanxi Provincial People's Hospital  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Di","sequence":"additional","affiliation":[{"name":"Department of Neurology Shaanxi Provincial People's Hospital  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Neurology Shaanxi Provincial People's Hospital  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a117094"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12576\u2010015\u20100382\u20107"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2018.04.008"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2016.08.017"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2018.09.006"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010017\u20100516\u20104"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201042633\u20109"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2017.04.014"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00064\u201019"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(21)00252\u20100"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.020129"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010004\u20100943\u2010y"},{"key":"e_1_2_9_14_1","doi-asserted-by":"crossref","unstructured":"Diprose W. 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