{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:20:24Z","timestamp":1791876024366,"version":"4.3.4"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Bipolar disorder (BD) is a mood disorder that affects millions worldwide. Up to half of the diagnosed patients are reported to not receive adequate treatment. This study aims to assess the relationship between the gut\u2013brain axis and BD and to discuss and compare the efficacy of varying methods of balancing gut microbiotas in BD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using PubMed, Embase, and Google Scholar from November 2021 to February 2022, we found 5310 studies on gut microbiota and its relation to BD. Using our inclusion criteria, 5283 studies were excluded. A total of 27 full\u2010text articles were assessed for eligibility. Also, 12 articles that met our criteria and eligibility criteria reported on 613 BD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Most studies analyzed found an overall difference in gut microbiota composition in bipolar patients compared to healthy controls, though the alterations found were not consistent. Differences in\n                      <jats:italic>Lactobacillus, Faecalibacterium<\/jats:italic>\n                      , and\n                      <jats:italic>Ruminococcus<\/jats:italic>\n                      abundance in BD compared to controls were found to be the most consistent across a few of the studies, but their effects on the gut\u2013brain axis conflicted. Probiotic supplementation was found to lower patient rehospitalizations and significantly improve depressive symptoms and cognitive impairments among patients with BD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Multiple studies included in this review point toward a possible link between BD and the gut microbiota. Probiotic supplements and other gut\u2010balancing therapies could serve as effective adjunctive methods for the treatment of BD. Notable limitations of the studies included for analysis were small sample sizes and majority observational study designs. Furthermore, the microbiota aberrations found in patients with BD were not consistent across multiple studies. Despite these limitations, our findings demonstrate the need for further research regarding the relationship between aberrant gut microbiota profiles and BD, as well as the effectiveness of gut balancing methods as adjunctive treatments.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.3037","type":"journal-article","created":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T00:56:15Z","timestamp":1682988975000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["A systematic review on gut\u2013brain axis aberrations in bipolar disorder and methods of balancing the gut microbiota"],"prefix":"10.1002","volume":"13","author":[{"given":"Crystal","family":"Obi\u2010Azuike","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Tulane University School of Medicine  New Orleans, Los Angeles USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruona","family":"Ebiai","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Ochsner Clinic Foundation  New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taneil","family":"Gibson","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Medicine and Health Sciences (UMHS)  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariana","family":"Hernandez","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Medicine and Health Sciences (UMHS)  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asma","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Lake Erie College of Osteopathic Medicine  Erie Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gibson","family":"Anugwom","sequence":"additional","affiliation":[{"name":"Menninger Department of Psychiatry &amp; Behavioral Sciences Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexsandra","family":"Urhi","sequence":"additional","affiliation":[{"name":"Department of Mental Health Federal Medical Center  Asaba, Delta State Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1014-9031","authenticated-orcid":false,"given":"Sakshi","family":"Prasad","sequence":"additional","affiliation":[{"name":"Department of Psychiatry National Pirogov Memorial Medical University  Vinnytsya, Vinnytsya Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara Ait","family":"Souabni","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Pharmacy of Marrakesh Cadi Ayyad University \u2010  Marrakech, Marrakech Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Funso","family":"Oladunjoye","sequence":"additional","affiliation":[{"name":"Menninger Department of Psychiatry &amp; Behavioral Sciences Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2018.00730"},{"issue":"4","key":"e_1_2_12_3_1","first-page":"28","article-title":"The gut\u2010brain axis: Influence of microbiota on mood and mental health","volume":"17","author":"Appleton J.","year":"2018","journal-title":"Integrative Medicine (Encinitas)"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2010.10.023"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2015.10.014"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2018.11.009"},{"key":"e_1_2_12_7_1","unstructured":"Bipolar Disorder\u2010Fact Sheet. 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