{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T03:42:03Z","timestamp":1790221323643,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T00:00:00Z","timestamp":1684108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>: Previous studies have revealed abnormal resting\u2010state brain activity in patients with end\u2010stage renal disease (ESRD); however, the results are inconsistent. Thus, we conducted a coordinate\u2010based meta\u2010analysis of whole\u2010brain resting\u2010state functional neuroimaging studies in ESRD to identify the most consistent neural activity alterations in ESRD patients and explore their relation to serological indicators.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      : A comprehensive literature search strategy was applied to select pertinent studies up to December 2022 in PubMed, Web of Science, and Embase databases. Voxel\u2010wise meta\u2010analysis was conducted via the latest meta\u2010analytic algorithm, seed\u2010based\n                      <jats:italic>d<\/jats:italic>\n                      mapping with permutation of subject images software. Meta\u2010regression analyses were also conducted to explore the potential effect of clinical variables on resting\u2010state neural activity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>: Eleven studies comprising 304 patients with ESRD and 296 healthy controls (HCs) were included. Compared with HCs, ESRD patients showed decreased brain activity in the default mode network (DMN) regions, including the bilateral anterior cingulate cortex\/medial prefrontal cortex, bilateral midcingulate cortex\/posterior cingulate cortex, bilateral precuneus, and right angular gyrus. The neural activities in the bilateral midcingulate cortex, bilateral midcingulate cortex\/posterior cingulate cortex, and right angular gyrus were significantly associated with serological indexes including hemoglobin, urea, and creatinine levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>: The present study provides a quantitative overview of brain activity alterations in patients with ESRD, and the results confirm the essential role of the DMN in ESRD patients, which may be the potential neural basis of their cognitive deficits. Additionally, some serological indicators may be used as predictive markers for progressive impairment of brain function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.3057","type":"journal-article","created":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T02:38:27Z","timestamp":1684204707000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Altered brain activity in patients with end\u2010stage renal disease: A meta\u2010analysis of resting\u2010state functional imaging"],"prefix":"10.1002","volume":"13","author":[{"given":"Wenjuan","family":"Song","sequence":"first","affiliation":[{"name":"Department of Radiology First People's Hospital of Linping District  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liuyan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Radiology First People's Hospital of Linping District  Hangzhou 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