{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:50:25Z","timestamp":1791309025315,"version":"4.3.1"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,1,16]],"date-time":"2015-01-16T00:00:00Z","timestamp":1421366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2015,2]]},"abstract":"Abstract<\/jats:title>\n \n Background and purpose<\/jats:title>\n \n Blood\u2010brain barrier disruption during the earliest phases of lesion formation in multiple sclerosis (\n MS<\/jats:styled-content>\n ) patients is commonly ascribed to perivenular inflammatory activity and is usually accompanied by increased diffusivity. Reduced diffusivity has also been shown in active lesions, albeit less frequently. This study aimed to characterize the development and natural history of contrast\u2010enhanced lesions by weekly following five relapsing remitting (\n RR<\/jats:styled-content>\n )\n MS<\/jats:styled-content>\n patients.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and methods<\/jats:title>\n \n Diffusion tensor imaging (\n DTI<\/jats:styled-content>\n ), perfusion imaging,\n FLAIR<\/jats:styled-content>\n and contrast\u2010enhanced 3D T1\u2010weighted\n MR<\/jats:styled-content>\n , were weekly performed on five untreated patients recently diagnosed with\n RR MS<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n All five patients showed significant increases of the apparent diffusion coefficient (\n ADC<\/jats:styled-content>\n ) in the lesions compared to the first time point. One of the five patients presented 98 active lesions on\n ADC<\/jats:styled-content>\n maps among which 36 had a volume larger than 10\u00a0mm\n 3<\/jats:sup>\n . In two of these lesions, a 1\u00a0week transient decrease in\n ADC<\/jats:styled-content>\n was detected at the time of the first gadolinium enhancement. Also, the perfusion analysis showed a concomitant increase in the relative cerebral blood volume.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n The infrequency detection of such\n ADC<\/jats:styled-content>\n decrease in a new lesion is probably due to its very short duration. This observation may be consistent with a hyper\u2010acute inflammatory stage concomitant with an increased reactional perfusion.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/brb3.307","type":"journal-article","created":{"date-parts":[[2015,1,16]],"date-time":"2015-01-16T01:51:25Z","timestamp":1421373085000},"source":"Crossref","is-referenced-by-count":13,"title":["Weekly multimodal\n MRI<\/scp>\n follow\u2010up of two multiple sclerosis active lesions presenting a transient decrease in\n ADC<\/scp>"],"prefix":"10.1002","volume":"5","author":[{"given":"Salem","family":"Hannoun","sequence":"first","affiliation":[{"name":"CREATIS \u2013 CNRS UMR 5220 & INSERM U1044 Universit\u00e9 Claude Bernard\u2010Lyon1 Villeurbanne France"},{"name":"Service de Neurologie A & EDMUS Coordinating Center for Multiple Sclerosis H\u00f4pital Neurologique Pierre Wertheimer Bron France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Am\u00e9d\u00e9e","family":"Roch","sequence":"additional","affiliation":[{"name":"Service de Radiologie Centre Hospitalier Lyon\u2010Sud Hospices Civils de Lyon Pierre\u2010B\u00e9nite France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francoise","family":"Durand\u2010Dubief","sequence":"additional","affiliation":[{"name":"CREATIS \u2013 CNRS UMR 5220 & INSERM U1044 Universit\u00e9 Claude Bernard\u2010Lyon1 Villeurbanne France"},{"name":"Service de Neurologie A & EDMUS Coordinating Center for Multiple Sclerosis H\u00f4pital Neurologique Pierre Wertheimer Bron France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Vukusic","sequence":"additional","affiliation":[{"name":"Service de Neurologie A & EDMUS Coordinating Center for Multiple Sclerosis H\u00f4pital Neurologique Pierre Wertheimer Bron France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Sappey\u2010Marinier","sequence":"additional","affiliation":[{"name":"CREATIS \u2013 CNRS UMR 5220 & INSERM U1044 Universit\u00e9 Claude Bernard\u2010Lyon1 Villeurbanne France"},{"name":"CERMEP \u2013 Imagerie du Vivant Groupement Hospitalier Est Bron France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles R.G.","family":"Guttmann","sequence":"additional","affiliation":[{"name":"Center for Neurological Imaging Brigham and Women's Hospital Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francois","family":"Cotton","sequence":"additional","affiliation":[{"name":"CREATIS \u2013 CNRS UMR 5220 & INSERM U1044 Universit\u00e9 Claude Bernard\u2010Lyon1 Villeurbanne France"},{"name":"Service de Radiologie Centre Hospitalier Lyon\u2010Sud Hospices Civils de Lyon Pierre\u2010B\u00e9nite France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,1,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/62.1.25"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(75)90138-0"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458512445407"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/0971-3026.32695"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2000.0740254.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1007\/s00234-002-0806-y","article-title":"Diffusion of water in large demyelinating lesions: a follow up study","volume":"44","author":"Castriota\u2010Scanderbeg A.","year":"2002","journal-title":"Neuroradiology"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0150-9861(06)77267-4"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1109\/42.585766"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(02)00421-5"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(200006)47:6<707::AID-ANA3>3.0.CO;2-Q"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.1032"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M603717200"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.6.882"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI11223"},{"key":"e_1_2_8_16_1","first-page":"1491","article-title":"Investigation of apparent diffusion coefficient and diffusion tensor anisotropy in acute and chronic multiple sclerosis lesions","volume":"20","author":"Tievsky A. 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