{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:31:47Z","timestamp":1786977107423,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T00:00:00Z","timestamp":1686096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2023,7]]},"abstract":"Abstract<\/jats:title>\n \n Background and purpose<\/jats:title>\n \n Quantitative measures have been proposed to aid the visual interpretation of amyloid PET. Our objective was to develop and validate quantitative software that enables calculation of the Centiloid (CL) scale and\n Z<\/jats:italic>\n \u2010score for amyloid PET with\n 18<\/jats:sup>\n F\u2010florbetapir.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This software was developed as a toolbox in statistical parametric mapping 12 running on MATLAB Runtime. For each participant's amyloid PET, this software calculates the CL scale using the standard MRI\u2010guided pipeline proposed by the Global Alzheimer's Association Interactive Network (GAAIN) and generates a\n Z<\/jats:italic>\n \u2010score map for comparison with a new amyloid\u2010negative database constructed from 20 healthy controls. In 23 cognitively impaired patients with suspected Alzheimer's disease,\n Z<\/jats:italic>\n \u2010score values for a target cortical area from the new database were compared with those from the GAAIN database constructed from 13 healthy controls. The CL values obtained using low\u2010dose CT of PET\/CT equipment were then compared with those obtained using MRI.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The CL calculation was validated with the\n 18<\/jats:sup>\n F\u2010florbetapir dataset in the GAAIN repository.\n Z<\/jats:italic>\n \u2010score values obtained from the new database were significantly higher (mean\u00a0\u00b1\u00a0standard deviation, 1.05\u00a0\u00b1\u00a00.77;\n p<\/jats:italic>\n \u00a0<\u00a0.0001) than those obtained from the GAAIN database. The use of low\u2010dose CT provided CL scales that were highly correlated with those obtained with MRI (\n R<\/jats:italic>\n 2<\/jats:sup>\n \u00a0=\u00a0.992) but showed a slight yet significant underestimation (\u22122.1\u00a0\u00b1\u00a04.2;\n p<\/jats:italic>\n \u00a0=\u00a0.013).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Our quantification software provides the CL scale and\n Z<\/jats:italic>\n \u2010score for measuring overall and local amyloid accumulation with the use of MRI or low\u2010dose CT.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/brb3.3092","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T01:57:25Z","timestamp":1686189445000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Development of software for measuring brain amyloid accumulation using\n 18<\/sup>\n F\u2010florbetapir PET and calculating global Centiloid scale and regional\n Z<\/i>\n \u2010score values"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6297-9897","authenticated-orcid":false,"given":"Hiroshi","family":"Matsuda","sequence":"first","affiliation":[{"name":"Drug Discovery and Cyclotron Research Center Southern Tohoku Research Institute for Neuroscience Koriyama Japan"},{"name":"Department of Radiology National Center of Neurology and Psychiatry Kodaira Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9942-6463","authenticated-orcid":false,"given":"Tsutomu","family":"Soma","sequence":"additional","affiliation":[{"name":"Software Development Department PDRadiopharma Inc. Tokyo Japan"},{"name":"Department of Nuclear Medicine and Medical Physics International University of Health and Welfare School of Medicine Narita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoji","family":"Okita","sequence":"additional","affiliation":[{"name":"Department of Psychiatry National Center of Neurology and Psychiatry Kodaira Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Shigemoto","sequence":"additional","affiliation":[{"name":"Department of Radiology National Center of Neurology and Psychiatry Kodaira Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Radiology National Center of Neurology and Psychiatry Kodaira 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