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Efforts to attenuate disease\u2010related brain and cognitive changes have been unsuccessful to date. Multidisciplinary rehabilitation, comprising motor and cognitive intervention, has been shown to positively impact on functional capacity, depression, quality of life and some aspects of cognition in individuals with <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>. This exploratory study aimed to evaluate, for the first time, whether multidisciplinary rehabilitation can slow further deterioration of disease\u2010related brain changes and related cognitive deficits in individuals with manifest <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifteen participants who manifest <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> undertook a multidisciplinary rehabilitation intervention spanning 9\u00a0months. The intervention consisted of once\u2010weekly supervised clinical exercise, thrice\u2010weekly self\u2010directed home based exercise and fortnightly occupational therapy. Participants were assessed using <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content> imaging and validated cognitive measures at baseline and after 9\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Participants displayed significantly increased gray matter volume in the right caudate and bilaterally in the dorsolateral prefrontal cortex after 9\u00a0months of multidisciplinary rehabilitation. Volumetric increases in gray matter were accompanied by significant improvements in verbal learning and memory (Hopkins Verbal Learning\u2010Test). A significant association was found between gray matter volume increases in the dorsolateral prefrontal cortex and performance on verbal learning and memory.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study provides preliminary evidence that multidisciplinary rehabilitation positively impacts on gray matter changes and cognitive functions relating to verbal learning and memory in individuals with manifest <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>. Larger controlled trials are required to confirm these preliminary findings.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.312","type":"journal-article","created":{"date-parts":[[2015,1,15]],"date-time":"2015-01-15T17:18:11Z","timestamp":1421342291000},"source":"Crossref","is-referenced-by-count":65,"title":["The effect of multidisciplinary rehabilitation on brain structure and cognition in Huntington's disease: an exploratory study"],"prefix":"10.1002","volume":"5","author":[{"given":"Travis M.","family":"Cruickshank","sequence":"first","affiliation":[{"name":"School of Medical Sciences Edith Cowan University Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A.","family":"Thompson","sequence":"additional","affiliation":[{"name":"School of Medical Sciences Edith Cowan University Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan F.","family":"Dom\u00ednguez D","sequence":"additional","affiliation":[{"name":"School of Psychological Sciences Monash University Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro P.","family":"Reyes","sequence":"additional","affiliation":[{"name":"School of Medical Sciences Edith Cowan University Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"Bynevelt","sequence":"additional","affiliation":[{"name":"Department of Surgery UWA and Neurological Intervention and Imaging Service of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nellie","family":"Georgiou\u2010Karistianis","sequence":"additional","affiliation":[{"name":"School of Psychological Sciences Monash University Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger A.","family":"Barker","sequence":"additional","affiliation":[{"name":"John van Geest Centre for Brain Repair Cambridge U.K"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mel R.","family":"Ziman","sequence":"additional","affiliation":[{"name":"School of Medical Sciences Edith Cowan University Perth Western Australia Australia"},{"name":"School of Pathology and Laboratory Medicine University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,1,15]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"657508","article-title":"A review of the effects of physical activity and exercise on cognitive and brain functions in older adults","volume":"2013","author":"Bherer L.","year":"2013","journal-title":"J. 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