{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T13:40:25Z","timestamp":1774878025623,"version":"3.50.1"},"reference-count":11,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T00:00:00Z","timestamp":1687219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Williams syndrome is an autosomal dominant multisystem disorder caused by a 1.5\u20131.8 Mb deletion on chromosome 7q11.23. It is characterized by facial deformations, cardiovascular abnormalities, developmental delays, gastrointestinal manifestations, and endocrine disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case description<\/jats:title>\n                    <jats:p>A 1\u2010year\u2010old child presenting with developmental delays, special facial features, gastrointestinal bleeding, renal calcium deposition, and hypotonia was admitted to the hospital for \u201chypercalcemia and gastrointestinal bleeding.\u201d Genetic testing showed a deletion mutation in the 7q11.23 region. Currently, the child receiving treatment to promote calcium excretion and rehabilitation training, but hypercalcemia has recurred.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The clinical phenotype of Williams syndrome is complex, and different severities, characterized by developmental delays, facial deformities, cardiovascular abnormalities, gastrointestinal symptoms and endocrine disorders, should be considered in children. The syndrome may require thorough genetic testing for diagnosis and early intervention treatment to improve patient quality of life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.3131","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T03:22:14Z","timestamp":1687231334000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A case report of Williams syndrome with main clinical manifestation of hypercalcemia and gastrointestinal bleeding as the main clinical manifestations, and with an accompanying literature review"],"prefix":"10.1002","volume":"13","author":[{"given":"Hong","family":"Meng","sequence":"first","affiliation":[{"name":"Department of Pediatrics Inner Mongolia Autonomous Region Maternal and Child Health Hospital Hohhot China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue\u2010Xin","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Inner Mongolia Autonomous Region Maternal and Child Health Hospital Hohhot China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui\u2010Min","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Inner Mongolia Autonomous Region Maternal and Child Health Hospital Hohhot China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Inner Mongolia Autonomous Region Maternal and Child Health Hospital Hohhot China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cha\u2010Gan\u2010Hu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Inner Mongolia Autonomous Region Maternal and Child Health Hospital Hohhot China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo\u2010Yan","family":"Xin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Inner Mongolia Autonomous Region Maternal and Child Health Hospital Hohhot China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4219-9997","authenticated-orcid":false,"given":"Yu\u2010Min","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Inner Mongolia Autonomous Region Maternal and Child Health Hospital Hohhot China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,6,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0903074"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ridd.2014.08.012"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.107.5.1192"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr\u20102018\u2010224513"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0887\u20108994(00)00177\u20106"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2012.05.036"},{"issue":"7","key":"e_1_2_7_8_1","first-page":"757","article-title":"Importance of dietary calcium and vitamin D in the treatment of hypercalcaemla in Williams\u2010Beuren syndrome","volume":"27","author":"Lameris A. L. L.","year":"2014","journal-title":"Journal of Pediatric Endocrinology & Metabolism: JPEM"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.30865"},{"issue":"7","key":"e_1_2_7_10_1","article-title":"Complicated diverticulitis in a 35\u2010year\u2010old patient with Williams syndrome: A case report","volume":"14","author":"Raber McKenzie M.","year":"2022","journal-title":"Cureus"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00240"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2016.08.027"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.3131","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T01:46:00Z","timestamp":1708393560000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.3131"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,20]]},"references-count":11,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1002\/brb3.3131"],"URL":"https:\/\/doi.org\/10.1002\/brb3.3131","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/BRB3.3131\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3131\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3131\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3131\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3131\/v1\/decision1","asserted-by":"object"}]},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,20]]},"assertion":[{"value":"2023-03-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e3131"}}