{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:05:00Z","timestamp":1753862700192,"version":"3.41.2"},"reference-count":60,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,2,13]],"date-time":"2015-02-13T00:00:00Z","timestamp":1423785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Estonian Ministry of Science and Education","award":["SF0180125s08"],"award-info":[{"award-number":["SF0180125s08"]}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The immune system has been increasingly implicated in the development of mood and anxiety disorders. Inhibitor of kappa light polypeptide gene enhancer in B cells, kinase epsilon (<jats:italic><jats:styled-content style=\"fixed-case\">IKBKE<\/jats:styled-content><\/jats:italic>) gene encodes <jats:styled-content style=\"fixed-case\">IKK<\/jats:styled-content><jats:italic>\u03b5<\/jats:italic> protein that is involved in innate immunity, predominantly antiviral response generation. It also bears pro\u2010inflammatory properties that could affect psychiatric outcomes. In order to investigate the possible role of <jats:italic><jats:styled-content style=\"fixed-case\">IKBKE<\/jats:styled-content><\/jats:italic> gene in major depressive disorder (<jats:styled-content style=\"fixed-case\">MDD<\/jats:styled-content>) and panic disorder (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>), we conducted a case\u2013control genetic association study concerning these disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In all, 14 <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s of <jats:italic><jats:styled-content style=\"fixed-case\">IKBKE<\/jats:styled-content><\/jats:italic> gene were genotyped in groups of 391 patients with <jats:styled-content style=\"fixed-case\">MDD<\/jats:styled-content> and 190 patients with <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> together with respective 389 and 371 healthy control individuals. The given groups were further divided by gender for additional analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Substantial genetic associations were revealed between <jats:italic><jats:styled-content style=\"fixed-case\">IKBKE<\/jats:styled-content><\/jats:italic> <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s and <jats:styled-content style=\"fixed-case\">MDD<\/jats:styled-content> (multiple testing adjusted <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) and suggestive associations in case of <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> (<jats:italic>P<\/jats:italic><jats:sub>adj<\/jats:sub>\u00a0&gt;\u00a00.05). In addition, two <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s that were only associated with <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> among males, also displayed significantly different allele frequencies compared to <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> females. This may indicate a specific role of these <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s in male <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>, but caution should be applied here due to the small size of the studied <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> males group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results of this study confirm our initial findings and indicate a possible role of <jats:italic><jats:styled-content style=\"fixed-case\">IKBKE<\/jats:styled-content><\/jats:italic> gene in mood and anxiety disorders.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.314","type":"journal-article","created":{"date-parts":[[2015,2,13]],"date-time":"2015-02-13T12:32:29Z","timestamp":1423830749000},"source":"Crossref","is-referenced-by-count":6,"title":["Polymorphisms of <i>IKBKE<\/i> gene are associated with major depressive disorder and panic disorder"],"prefix":"10.1002","volume":"5","author":[{"given":"Tanel","family":"Traks","sequence":"first","affiliation":[{"name":"Department of Physiology University of Tartu Tartu Estonia"},{"name":"Centre of Excellence for Translational Medicine University of Tartu Tartu Estonia"},{"name":"Department of Dermatology and Venerology University of Tartu Tartu Estonia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kati","family":"Koido","sequence":"additional","affiliation":[{"name":"Department of Physiology University of Tartu Tartu Estonia"},{"name":"Centre of Excellence for Translational Medicine University of Tartu Tartu Estonia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roman","family":"Bal\u00f5t\u0161ev","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Tartu Tartu 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