{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:25:06Z","timestamp":1777613106375,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T00:00:00Z","timestamp":1688515200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R15NS088776"],"award-info":[{"award-number":["R15NS088776"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Fragile X syndrome is the main monogenetic cause of intellectual disability and autism. Alterations in the immune system are commonly found in these developmental disorders. We and others have demonstrated that\n                      <jats:italic>Fmr1<\/jats:italic>\n                      mutant mice present an altered response to immune stimuli. However, whether this altered immune response can influence the\n                      <jats:italic>Fmr1<\/jats:italic>\n                      mutant behavioral outcomes in response to inflammation has not been fully investigated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      In the current study, we examine the behavioral sickness response of male wildtype and knockout \u00a0mice to the innate immune stimulus lipopolysaccharide (LPS) (0.1\u00a0mg\/kg) to determine if\n                      <jats:italic>Fmr1<\/jats:italic>\n                      mutants have altered sickness behavior. We used an enzyme\u2010linked immunosorbent assay (ELISA) to measure changes in the cytokine interleukin\u20106 (IL\u20106) to determine that inflammation was induced in the mice. Sickness behavior was assessed in a wheel\u2010running paradigm, and a tail suspension test was used to assess the depressive\u2010like phenotype that follows sickness behavior in response to LPS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The ELISA using blood serum confirmed a significant increase in IL\u20106 in mice that were treated with LPS. Treated\n                      <jats:italic>Fmr1<\/jats:italic>\n                      mutants exhibited decreased distance traveled in the wheel running after LPS administration, similar to treated controls. Another cohort of animals treated with LPS were tested in the tail suspension test and exhibited no alterations in immobility time in response to LPS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Together, our data suggest that\n                      <jats:italic>Fmr1<\/jats:italic>\n                      mutant mice do not have altered sickness behavior in response to a low dose of LPS.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.3142","type":"journal-article","created":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T22:28:11Z","timestamp":1688596091000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Lipopolysaccharide\u2010induced sickness behavior is not altered in male\n                    <i>Fmr1<\/i>\n                    \u2010deficient mice"],"prefix":"10.1002","volume":"13","author":[{"given":"Danielle","family":"Santana\u2010Coelho","sequence":"first","affiliation":[{"name":"Department of Psychology and Neuroscience Baylor University Waco Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha L.","family":"Hodges","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Studies Baylor University Waco Texas USA"},{"name":"Department of Biology Baylor University Waco Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saul I.","family":"Quintero","sequence":"additional","affiliation":[{"name":"Department of Psychology and Neuroscience Baylor University Waco Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paige D.","family":"Womble","sequence":"additional","affiliation":[{"name":"Department of Psychology and Neuroscience Baylor University Waco Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6426-2355","authenticated-orcid":false,"given":"D. 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