{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:01:54Z","timestamp":1772118114875,"version":"3.50.1"},"reference-count":67,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T00:00:00Z","timestamp":1689033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Secondary tumoral parkinsonism is a rare phenomenon that develops as a direct or indirect result of brain neoplasms or related conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The first objective was to explore to what extent brain neoplasms, cavernomas, cysts, paraneoplastic syndromes (PNSs), and oncological treatment methods cause parkinsonism. The second objective was to investigate the effect of dopaminergic therapy on the symptomatology in patients with tumoral parkinsonism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic literature review was conducted in the databases PubMed and Embase. Search terms like \u201csecondary parkinsonism,\u201d \u201castrocytoma,\u201d and \u201ccranial irradiation\u201d were used. Articles fulfilling inclusion criteria were included in the review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Out of 316 identified articles from the defined database search strategies, 56 were included in the detailed review. The studies, which were mostly case reports, provided research concerning tumoral parkinsonism and related conditions. It was found that various types of primary brain tumors, such as astrocytoma and meningioma, and more seldom brain metastases, can cause tumoral parkinsonism. Parkinsonism secondary to PNSs, cavernomas, cysts, as well as oncological treatments was reported. Twenty\u2010five of the 56 included studies had tried initiating dopaminergic therapy, and of these 44% reported no, 48% low to moderate, and 8% excellent effect on motor symptomatology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Brain neoplasms, PNSs, certain intracranial malformations, and oncological treatments can cause parkinsonism. Dopaminergic therapy has relatively benign side effects and may relieve motor and nonmotor symptomatology in patients with tumoral parkinsonism. Dopaminergic therapy, particularly levodopa, should therefore be considered in patients with tumoral parkinsonism.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.3151","type":"journal-article","created":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T15:29:39Z","timestamp":1689089379000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Tumoral parkinsonism\u2014Parkinsonism secondary to brain tumors, paraneoplastic syndromes, intracranial malformations, or oncological intervention, and the effect of dopaminergic treatment"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4933-9286","authenticated-orcid":false,"given":"Gustav","family":"Cedergren Weber","sequence":"first","affiliation":[{"name":"Division of Neurology, Department of Clinical Sciences Lund, Faculty of Medicine Lund University Lund Sweden"},{"name":"Department of Neurology, Rehabilitation Medicine, Memory and Geriatrics Sk\u00e5ne University Hospital Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2577-8607","authenticated-orcid":false,"given":"Jonathan","family":"Timpka","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Clinical Sciences Lund, Faculty of Medicine Lund University Lund Sweden"},{"name":"Department of Neurology, Rehabilitation Medicine, Memory and Geriatrics Sk\u00e5ne University Hospital Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6742-1825","authenticated-orcid":false,"given":"Anna","family":"Rydelius","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Clinical Sciences Lund, Faculty of Medicine Lund University Lund Sweden"},{"name":"Department of Neurology, Rehabilitation Medicine, Memory and Geriatrics Sk\u00e5ne University Hospital Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6536-2107","authenticated-orcid":false,"given":"Johan","family":"Bengzon","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Clinical Sciences, Kamprad laboratory Lund University Lund Sweden"},{"name":"Department of Neurosurgery Sk\u00e5ne University Hospital Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0756-7478","authenticated-orcid":false,"given":"Per","family":"Odin","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Clinical Sciences Lund, Faculty of Medicine Lund University Lund Sweden"},{"name":"Department of Neurology, Rehabilitation Medicine, Memory and Geriatrics Sk\u00e5ne University Hospital Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,7,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.12890\/2019_001055"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/00207450903139648"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.49.12.1457"},{"issue":"2","key":"e_1_2_10_5_1","first-page":"S222","article-title":"Actinic parkinsonism: A case report","volume":"36","author":"Artusi C. A.","year":"2015","journal-title":"Neurological Sciences"},{"issue":"1","key":"e_1_2_10_6_1","first-page":"123","article-title":"A unique pediatric case of radiation\u2010induced parkinsonism","volume":"9","author":"Bernard G.","year":"2011","journal-title":"Journal of Pediatric Neurology"},{"issue":"1","key":"e_1_2_10_7_1","first-page":"40","article-title":"Movement disorders caused by brain tumours","volume":"47","author":"Bhatoe H. S.","year":"1999","journal-title":"Neurology India"},{"issue":"5","key":"e_1_2_10_8_1","first-page":"124","article-title":"A Parkinson\u2010like syndrome as side effect of chemotherapy with vincristine and adriamycin in a child with acute leukaemia","volume":"31","author":"Boranic M.","year":"1979","journal-title":"Biomedicine"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.01044"},{"issue":"8","key":"e_1_2_10_10_1","first-page":"658","article-title":"Parkinsonism as an initial manifestation of brain tumor","volume":"63","author":"Chang D. C.","year":"2000","journal-title":"Zhonghua Yi Xue Za Zhi = Chinese Medical Journal; Free China Ed"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3340\/jkns.2012.51.3.144"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531\u20108257(199903)14:2<364::AID\u2010MDS1028>3.0.CO;2\u2010I"},{"issue":"4","key":"e_1_2_10_13_1","first-page":"234","article-title":"Hemiparkinsonism revealing an infiltrating low\u2010grade oligodendroglial tumor","volume":"40","author":"S\u00e8ze J.","year":"1998","journal-title":"European Neurology"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410110313"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0887\u20108994(02)00620\u20103"},{"key":"e_1_2_10_16_1","first-page":"S388","article-title":"The use of basal ganglia drugs as palliative therapy for secondary parkinsonism in malignant CNS tumor patients: A University of Florida experience","volume":"27","author":"Dunbar E. M.","year":"2012","journal-title":"Movement Disorders"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2005.07.003"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.irn.2019.10.004"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007611\u2010199703000\u201000022"},{"key":"e_1_2_10_20_1","first-page":"266","article-title":"Post\u2010irradiation parkinsonism: An institutional series","volume":"26","author":"Franchino F.","year":"2019","journal-title":"European Journal of Neurology"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00687019"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870040206"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/practneurol\u20102011\u2010000071"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/NRL.0b013e31816c43ea"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000015261"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.irn.2019.10.010"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/1752\u20101947\u20104\u2010218"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870090324"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102377\u201011\u2010137"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.15280\/jlm.2014.4.2.101"},{"issue":"12","key":"e_1_2_10_31_1","article-title":"[Subacute parkinsonism as first symptom of primary CNS lymphoma]","volume":"184","author":"Kirkedal C. H.","year":"2022","journal-title":"Ugeskrift for Laeger"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuchi.2016.06.002"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01404943"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v7.i23.4052"},{"issue":"1","key":"e_1_2_10_35_1","first-page":"87","article-title":"Could Parkinsonism complicate craniotomy and excision of convexity meningioma? A case report","volume":"37","author":"Malomo A. O.","year":"2008","journal-title":"African Journal of Medicine and Medical Sciences"},{"issue":"3","key":"e_1_2_10_36_1","first-page":"341","article-title":"Parkinsonism following i.v. administration of high\u2010dose metoclopramide used as an antiemetic agent during cancer chemotherapy","volume":"69","author":"Markman M.","year":"1985","journal-title":"Cancer Treatment Reports"},{"key":"e_1_2_10_37_1","first-page":"S322","article-title":"Meningioma presenting as Parkinsonism","volume":"30","author":"McMahan S. A.","year":"2015","journal-title":"Movement Disorders"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1227\/00006123\u2010199305000\u201000019"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2020.105664"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410370616"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.33160\/yam.2018.09.001"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.2739\/kurumemedj.30.97"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.3892\/mco.2021.2257"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.51.7.999\u2010a"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.50.10.1386"},{"key":"e_1_2_10_46_1","first-page":"172","article-title":"Persistent parkinsonian syndrome induced by radiotherapy and chemotherapy","volume":"91","author":"Pereira L. C.","year":"2013","journal-title":"Stereotactic and Functional Neurosurgery"},{"issue":"3","key":"e_1_2_10_47_1","first-page":"211","article-title":"Primary brain tumors in adults: Diagnosis and treatment","volume":"93","author":"Perkins A.","year":"2016","journal-title":"American Family Physician"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531\u20108257(199909)14:5<842::AID\u2010MDS1020>3.0.CO;2\u2010O"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12950"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/0887\u20108994(94)90045\u20100"},{"issue":"4","key":"e_1_2_10_51_1","article-title":"Parkinson's Syndrome after cranial radiotherapy: A case report","volume":"14","author":"Reddy K. K.","year":"2022","journal-title":"Cureus"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.151179"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2017.04.004"},{"key":"e_1_2_10_54_1","first-page":"1110","article-title":"2 clinical cases of secondary parkinsonism due to cerebral glioblastoma","volume":"27","author":"Ruiz\u2010Escribano Menchen L.","year":"2020","journal-title":"European Journal of Neurology"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.4103\/1793-5482.121688"},{"issue":"2","key":"e_1_2_10_56_1","first-page":"190","article-title":"An unusual case of Parkinsonism secondary to right parasagittal meningioma","volume":"48","author":"Saleem S. M.","year":"2000","journal-title":"Neurology India"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1159\/000518198"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.inat.2018.10.018"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.10111"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.51.5.730"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2009.177683"},{"key":"e_1_2_10_62_1","first-page":"S292","article-title":"Paraneoplastic parkinsonism: A rare cause of symptomatic parkinsonism","volume":"28","author":"Topcular B.","year":"2013","journal-title":"Movement Disorders"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1054\/jocn.2000.0895"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2005.10.021"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182267bc4"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531\u20108257(199903)14:2<366::AID\u2010MDS1029>3.0.CO;2\u2010D"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883\u2010020\u201001670\u2010y"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2021.120014"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.3151","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T01:46:21Z","timestamp":1708393581000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.3151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,11]]},"references-count":67,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1002\/brb3.3151"],"URL":"https:\/\/doi.org\/10.1002\/brb3.3151","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/BRB3.3151\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3151\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3151\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3151\/v2\/decision1","asserted-by":"object"}]},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,11]]},"assertion":[{"value":"2023-03-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e3151"}}