{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:21:13Z","timestamp":1793038873537,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T00:00:00Z","timestamp":1689552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>: Parkinson's disease (PD) is a neurodegenerative disorder that affects millions of people worldwide. Subthalamic nucleus (STN) deep brain stimulation (DBS) has been shown to be an effective treatment for PD; however, the effects of this surgery on cerebral metabolism and presynaptic dopamine transporter (DAT) distribution are still being studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      : In this study, we included 12 PD patients (6 male and 6 female) who underwent STN\u2010DBS surgery and had both\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010FDG and\n                      <jats:sup>11<\/jats:sup>\n                      C\u2010CFT PET\/CT imaging before and 1 year after the surgery. We used paired\n                      <jats:italic>t<\/jats:italic>\n                      \u2010tests to identify changes in cerebral metabolism and calculated PD\u2010related metabolic covariance pattern (PDRP) scores. We also assessed the uptake of\n                      <jats:sup>11<\/jats:sup>\n                      C\u2010CFT in the striatum using striatal\u2010to\u2010occipital ratios (SORs).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      : One year after surgery, we observed significant reductions in tremor, rigidity, akinesia, postural instability\/gait disturbance, and Unified Parkinson's Disease Rating Scale Part III scores (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.01,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.001,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.001,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.001, and\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.001, respectively). Hamilton Depression Rating Scale and quality of life (PDQ\u201039 SI) were also significantly reduced (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.05 and\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.01, respectively). The mean PDRP score decreased by 37% from 13.0\u00a0\u00b1\u00a06.6 to 8.2\u00a0\u00b1\u00a07.9 after STN\u2010DBS surgery (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.05). We observed decreased\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010FDG uptake in several areas, including the temporal lobe (BA22), thalamus, putamen, and cingulate gyrus (BA24), whereas it was increased in the supplementary motor area, postcentral gyrus, lingual gyrus, and precuneus (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.05). SORs of\n                      <jats:sup>11<\/jats:sup>\n                      C\u2010CFT in the bilateral caudate nucleus and ipsilateral posterior putamen were significantly decreased compared to preoperative levels (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>: Our findings suggest that STN\u2010DBS surgery modifies the metabolic network of PD patients and improves motor symptoms, depression, and quality of life. However, it does not prevent the decrease of DAT in striatal areas.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.3172","type":"journal-article","created":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T12:33:36Z","timestamp":1689597216000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effects of STN\u2010DBS surgery on cerebral glucose metabolism and distribution of DAT in Parkinson's disease"],"prefix":"10.1002","volume":"13","author":[{"given":"Ganhua","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine The First Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinchong","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine The First Affiliated Hospital of Sun Yat\u2010sen University Guangzhou 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