{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T18:21:31Z","timestamp":1782498091885,"version":"3.54.5"},"reference-count":49,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T00:00:00Z","timestamp":1690934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To investigate the association between cerebral amyloid deposition and long\u2010term cognitive outcomes in patients with hemorrhagic small vessel disease (SVD) and survivors of intracerebral hemorrhage (ICH).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients experiencing an ICH without overt dementia were prospectively recruited (<jats:italic>n<\/jats:italic>\u00a0=\u00a068) for brain MRI and Pittsburgh compound B (PiB) positron emission tomography scans at baseline. Cognitive function was assessed using the mini\u2010mental status examination (MMSE) and clinical dementia rating after an overall median follow\u2010up of 3.8 years. A positive amyloid scan was defined as a global PiB standardized uptake value ratio &gt;1.2. Associations between follow\u2010up cognitive outcomes and neuroimaging markers were explored using multivariable Cox regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PiB(+) patients were older (72.1\u00a0\u00b1\u00a07.8 vs. 59.9\u00a0\u00b1\u00a011.7, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.002) and more frequently had cerebral amyloid angiopathy (CAA) (63.6% vs. 15.8%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.002) than PiB(\u2212) patients. PiB(+) was associated with a higher risk of dementia conversion (32.9 vs. 4.0 per 100\u2010person\u2010years, hazard ratio [HR]\u00a0=\u00a015.7 [3.0\u201380.7], <jats:italic>p<\/jats:italic>\u00a0=\u00a0.001) and MMSE score decline (58.8 vs. 9.9 per 100\u2010person\u2010years, HR\u00a0=\u00a06.2 [1.9\u201320.0], <jats:italic>p<\/jats:italic>\u00a0=\u00a0.002). In the non\u2010CAA subgroup (<jats:italic>n<\/jats:italic>\u00a0=\u00a052), PiB(+) remained an independent predictor of dementia conversion, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.04). In the Cox models, PiB(+) was an independent predictor of dementia conversion (HR\u00a0=\u00a015.8 [2.6\u201395.4], <jats:italic>p<\/jats:italic>\u00a0=\u00a0.003) and MMSE score decline (HR\u00a0=\u00a05.7 [1.6\u201320.3], <jats:italic>p<\/jats:italic>\u00a0=\u00a0.008) after adjusting for confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cerebral amyloid deposition potentially contributes to long\u2010term cognitive decline in SVD\u2010related ICH.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.3189","type":"journal-article","created":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T06:49:07Z","timestamp":1691045347000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Cerebral amyloid deposition predicts long\u2010term cognitive decline in hemorrhagic small vessel disease"],"prefix":"10.1002","volume":"13","author":[{"given":"Ya\u2010Chin","family":"Tsai","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine National Taiwan University Hospital Hsin\u2010Chu Branch Hsinchu Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4721-1468","authenticated-orcid":false,"given":"Hsin\u2010Hsi","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Neurology National Taiwan University Hospital Bei\u2010Hu Branch Taipei Taiwan"},{"name":"Department of Neurology National Taiwan University Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia\u2010Ju","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine National Taiwan University Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng\u2010Sian","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Neurology National Taiwan University Hospital Bei\u2010Hu Branch Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya\u2010Fang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging National Taiwan University Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiann\u2010Shing","family":"Jeng","sequence":"additional","affiliation":[{"name":"Department of Neurology National Taiwan University Hospital Bei\u2010Hu Branch Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Kai","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Neurology National Taiwan University Hospital Bei\u2010Hu Branch Taipei Taiwan"},{"name":"Department of Neurology National Taiwan 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