{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T02:20:07Z","timestamp":1788315607725,"version":"build-2803163510"},"reference-count":57,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T00:00:00Z","timestamp":1698364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82060232"],"award-info":[{"award-number":["82060232"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160225"],"award-info":[{"award-number":["82160225"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Ischemic cerebrovascular disease (ICVD) is one of three fatal diseases in humans, along with heart disease and malignant tumors. Cerebral ischemia\/reperfusion injury (CI\/RI) is the primary cause of ICVD. Recently, seipin was reported to be crucial for lipid droplet formation, hepatic steatosis, and axonal atrophy. However, the function and mechanism of seipin in CI\/RI has not been explicitly stated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Oxygen\u2013glucose deprivation\/reoxygenation (OGD\/R) hippocampal neuron cell line (HT\u201022) and middle cerebral artery occlusion (MCAO) in rats were established. The levels of apoptosis\u2010 and autophagy\u2010related proteins and seipin were confirmed by western blot. Cell proliferation was assessed with CCK\u20108, and ischemic infarction and pathological structure were monitored by TTC and H&amp;E staining, and tissue apoptosis was assessed through TUNEL assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The proliferative activity was decreased, and apoptosis and autophagy pathways could also be induced in the OGD\/R HT\u201022 cells. Seipin overexpression accelerated viability and inhibited apoptosis and autophagy in the OGD\/R HT\u201022 cells. Moreover, the data revealed that seipin overexpression could also attenuate cerebral infarction, apoptosis. Autophagy pathways could be repressed by seipin in the MCAO rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Seipin has a protective role against CI\/RI in rats, and its mechanism might be relevant to the suppression of apoptosis and autophagy, suggesting that seipin might be a latent target for CI\/RI.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.3195","type":"journal-article","created":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T05:00:00Z","timestamp":1698469200000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Seipin overexpression attenuates cerebral ischemia\u2010reperfusion injury via preventing apoptosis and autophagy"],"prefix":"10.1002","volume":"13","author":[{"given":"Xiaoxi","family":"Zhu","sequence":"first","affiliation":[{"name":"Key Laboratory of Molecular Biology School of Basic Medical Science of Guizhou Medical University Guiyang City China"},{"name":"Cell engineering Laboratory Affiliated Hospital of Zunyi Medical University Zunyi City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqiong","family":"An","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Biology School of Basic Medical Science of Guizhou Medical University Guiyang City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Biology School of Basic Medical Science of Guizhou Medical University Guiyang City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongfen","family":"Guo","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Biology School of Basic Medical Science of Guizhou Medical University Guiyang City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Xie","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Biology School of Basic Medical Science of Guizhou Medical University Guiyang City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bi","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Biology School of Basic Medical Science of Guizhou Medical University Guiyang City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Huang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Biology School of Basic Medical Science of Guizhou Medical University Guiyang City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0567-5643","authenticated-orcid":false,"given":"Wenfeng","family":"Yu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Biology School of Basic Medical Science of Guizhou Medical University Guiyang City China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101792"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2018.10.001"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2019.03.023"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2022.2038448"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/5207608"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddv156"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745\u20107270.2005.00108.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M017566"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00298"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1134\/S0006297919110154"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.1841"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2697"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.024159"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2017.465"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010018\u20101282\u20106"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118660"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2019.12.021"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.2810"},{"key":"e_1_2_9_20_1","first-page":"98","article-title":"Protective effects of apocynin and melatonin on ovarian ischemia\/reperfusion injury in rats","volume":"48","author":"\u0130\u015fg\u00fcder \u00c7. 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