{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T23:50:35Z","timestamp":1790466635048,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,3,25]],"date-time":"2015-03-25T00:00:00Z","timestamp":1427241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pain is a common nonmotor symptom in Parkinson's disease (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>). The pathophysiology of pain in <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> is not well understood. Pain characteristics have rarely been studied in atypical parkinsonian disorders such as Multiple System Atrophy (<jats:styled-content style=\"fixed-case\">MSA<\/jats:styled-content>) and Progressive Supranuclear Palsy (<jats:styled-content style=\"fixed-case\">PSP<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim of the study<\/jats:title><jats:p>We aimed to evaluate pain intensity, location, and associated symptoms in atypical parkinsonian disorders compared to <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010one patients with <jats:styled-content style=\"fixed-case\">MSA<\/jats:styled-content>, 16 patients with <jats:styled-content style=\"fixed-case\">PSP<\/jats:styled-content>, and 65 patients with <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> were screened for pain using question 1.9 of the <jats:styled-content style=\"fixed-case\">MDS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">UPDRS<\/jats:styled-content>. Pain intensity was quantified using the short form McGill Pain Questionnaire (<jats:styled-content style=\"fixed-case\">SFMPQ<\/jats:styled-content>). Pain locations were documented. Motor disability was measured using <jats:styled-content style=\"fixed-case\">UPDRS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>. Affective symptoms were assessed using the Hospital Anxiety and Depression Scale (<jats:styled-content style=\"fixed-case\">HADS<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Pain was significantly more common and more severe in <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MSA<\/jats:styled-content> compared to <jats:styled-content style=\"fixed-case\">PSP<\/jats:styled-content> (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.01). Pain locations were similar with limb pain being the most common followed by neck and back pain. Pain intensity correlated with <jats:styled-content style=\"fixed-case\">HADS<\/jats:styled-content> scores but not motor severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Pain is more common and more intense in <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MSA<\/jats:styled-content> than <jats:styled-content style=\"fixed-case\">PSP<\/jats:styled-content>. Differences in distribution of neurodegenerative pathologies may underlie these differential pain profiles.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.320","type":"journal-article","created":{"date-parts":[[2015,3,26]],"date-time":"2015-03-26T14:26:23Z","timestamp":1427379983000},"source":"Crossref","is-referenced-by-count":39,"title":["Pain in multiple system atrophy and progressive supranuclear palsy compared to Parkinson's disease"],"prefix":"10.1002","volume":"5","author":[{"given":"Lewis","family":"Kass\u2010Iliyya","sequence":"first","affiliation":[{"name":"Department of Neurology Greater Manchester Neurosciences Centre Salford Royal NHS Foundation Trust Stott Lane M6 8HD Salford U.K"},{"name":"Centre for Clinical and Cognitive Neurosciences Institute of Brain Behaviour and Mental Health University of Manchester Manchester U.K"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Kobylecki","sequence":"additional","affiliation":[{"name":"Department of Neurology Greater Manchester Neurosciences Centre Salford Royal NHS Foundation Trust Stott Lane M6 8HD Salford U.K"},{"name":"Centre for Clinical and Cognitive Neurosciences Institute of Brain Behaviour and Mental Health University of Manchester Manchester U.K"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn R.","family":"McDonald","sequence":"additional","affiliation":[{"name":"Centre for Clinical and Cognitive Neurosciences Institute of Brain Behaviour and Mental Health University of Manchester Manchester U.K"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Gerhard","sequence":"additional","affiliation":[{"name":"Department of Neurology Greater Manchester Neurosciences Centre Salford Royal NHS Foundation Trust Stott Lane M6 8HD Salford U.K"},{"name":"Centre for Clinical and Cognitive Neurosciences Institute of Brain Behaviour and Mental Health University of Manchester Manchester U.K"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monty A.","family":"Silverdale","sequence":"additional","affiliation":[{"name":"Department of Neurology Greater Manchester Neurosciences Centre Salford Royal NHS Foundation Trust Stott Lane M6 8HD Salford U.K"},{"name":"Centre for Clinical and Cognitive Neurosciences Institute of Brain Behaviour and Mental Health University of Manchester Manchester U.K"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2008.12.004"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(00)00482-6"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-6-27"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20629"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.09.013"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-009-5255-7"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000324625.00404.15"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2010.07.024"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.3.181"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.47.1.1"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(87)91074-8"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22142"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2013.09.035"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22794"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2011.11.010"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2012.54"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1983.tb09716.x"}],"container-title":["Brain 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