{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:00:44Z","timestamp":1772118044164,"version":"3.50.1"},"reference-count":51,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T00:00:00Z","timestamp":1693267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["15K09920"],"award-info":[{"award-number":["15K09920"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18K07712"],"award-info":[{"award-number":["18K07712"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21K07593"],"award-info":[{"award-number":["21K07593"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23K08518"],"award-info":[{"award-number":["23K08518"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Meningiomas are the most common primary central nervous system tumors. Predicting the grade and proliferative activity of meningiomas would influence therapeutic strategies. We aimed to apply the multiple parameters from preoperative diffusion tensor images for predicting meningioma grade and proliferative activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Nineteen patients with low\u2010grade meningiomas and eight with high\u2010grade meningiomas were included. For the prediction of proliferative activity, the patients were divided into two groups: Ki\u201067 monoclonal antibody labeling index (MIB\u20101 LI)\u00a0&lt;\u00a05% (lower MIB\u20101 LI group;\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a018) and MIB\u20101 LI\u00a0\u2265\u00a05% (higher MIB\u20101 LI group;\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a09). Six features, diffusion\u2010weighted imaging, fractional anisotropy, mean, axial, and radial diffusivities, and raw T2 signal with no diffusion weighting, were extracted as multiple parameters from diffusion tensor imaging. The two\u2010level clustering approach for a self\u2010organizing map followed by the K\u2010means algorithm was applied to cluster a large number of input vectors with the six features. We also validated whether the diffusion tensor\u2010based clustered image (DTcI) was helpful for predicting preoperative meningioma grade or proliferative activity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The sensitivity, specificity, accuracy, and area under the curve of receiver operating characteristic curves from the 16\u2010class DTcIs for differentiating high\u2010 and low\u2010grade meningiomas were 0.870, 0.901, 0.891, and 0.959, and those from the 10\u2010class DTcIs for differentiating higher and lower MIB\u20101 LIs were 0.508, 0.770, 0.683, and 0.694, respectively. The log\u2010ratio values of class numbers 13, 14, 15, and 16 were significantly higher in high\u2010grade meningiomas than in low\u2010grade meningiomas (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.001). With regard to MIB\u20101 LIs, the log\u2010ratio values of class numbers 8, 9, and 10 were higher in meningiomas with higher MIB\u20101 groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The multiple diffusion tensor imaging\u2010based parameters from the voxel\u2010based DTcIs can help differentiate between low\u2010 and high\u2010grade meningiomas and between lower and higher proliferative activities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.3201","type":"journal-article","created":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T02:40:53Z","timestamp":1693363253000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Voxel\u2010based clustered imaging by multiparameter diffusion tensor images for predicting the grade and proliferative activity of meningioma"],"prefix":"10.1002","volume":"13","author":[{"given":"Yuki","family":"Takahashi","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Kyoto University Graduate School of Medicine Kyoto Japan"},{"name":"Human Brain Research Center Kyoto University Graduate School of Medicine Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoya","family":"Oishi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Kyoto University Graduate School of Medicine Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9615-2353","authenticated-orcid":false,"given":"Yukihiro","family":"Yamao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Kyoto University Graduate School of Medicine Kyoto Japan"},{"name":"Human Brain Research Center Kyoto University Graduate School of Medicine Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeharu","family":"Kunieda","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Ehime University Graduate School of Medicine Toon Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Kyoto University Graduate School of Medicine Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidenao","family":"Fukuyama","sequence":"additional","affiliation":[{"name":"Yasu City Hospital Yasu Japan"},{"name":"Kyoto University Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumu","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Kyoto University Graduate School of Medicine Kyoto Japan"},{"name":"Stroke Support Center Kyoto University Hospital Kyoto Japan"},{"name":"Momoya Disease Support Center Kyoto University Hospital Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiki","family":"Arakawa","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Kyoto University Graduate School of Medicine Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046\u20108177(98)90010\u20107"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.5858\/1999\u2010123\u20100793\u2010HFAMLI"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2010.09.002"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2013.11.003"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053\u20108119(03)00336\u20107"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmrb.1994.1037"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756\u2010200207190\u201000024"},{"key":"e_1_2_9_9_1","first-page":"EC14","article-title":"The study of MIB\u20101 LI and CD 34 as a marker of proliferative activity and angiogenesis in different grades of meningioma","volume":"10","author":"Bohra H.","year":"2016","journal-title":"Journal of Clinical Diagnostic Research"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004728\u2010200411000\u201000003"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/RCT.0b013e318261e913"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004728\u2010199101000\u201000005"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1157379"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060\u2010009\u20109934\u20100"},{"key":"e_1_2_9_15_1","first-page":"65","article-title":"Appearance of meningiomas on diffusion\u2010weighted images: Correlating diffusion constants with histopathologic findings","volume":"22","author":"Filippi C. G.","year":"2001","journal-title":"Ajnr American Journal of Neuroradiology"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrnm.2013.04.005"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234\u2010006\u20100094\u2010z"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060\u2010010\u20100348\u20109"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2009.09.018"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep30344"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2014.08.001"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/01616412.1999.11741004"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910340111"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurad.2010.03.001"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.3340\/jkns.2011.49.1.26"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1159\/000338253"},{"key":"e_1_2_9_27_1","first-page":"1081","article-title":"The role of diffusion\u2010weighted imaging in patients with brain tumors","volume":"22","author":"Kono K.","year":"2001","journal-title":"Ajnr American Journal of Neuroradiology"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002340050450"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010007\u20100243\u20104"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010016\u20101545\u20101"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004010050458"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A0996"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478\u2010200104000\u201000006"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100029\u20101243244"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097\u20100142(19941215)74:12<3176::AID\u2010CNCR2820741217>3.0.CO;2\u2010N"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/not151"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330\u2010018\u20105830\u20103"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.31557\/APJCP.2023.24.3.819"},{"key":"e_1_2_9_39_1","first-page":"47","article-title":"MIB\u20101 counting methods in meningiomas and agreement among pathologists","volume":"30","author":"Rezanko T.","year":"2008","journal-title":"Analytical and Quantitative Cytology and Histology"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102105\u201012\u201077"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00701\u2010010\u20100657\u2010y"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2011.06.031"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330\u2010023\u201009505\u20103"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.07.051"},{"key":"e_1_2_9_45_1","first-page":"969","article-title":"Diffusion\u2010weighted MR imaging of intracerebral masses: Comparison with conventional MR imaging and histologic findings","volume":"22","author":"Stadnik T. W.","year":"2001","journal-title":"Ajnr American Journal of Neuroradiology"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.13.11637"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.181.6.1811463"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1170"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1080\/02688690400005008"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.3844\/jcssp.2010.363.368"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2014.10.023"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2016.05.005"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.3201","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T00:34:06Z","timestamp":1697157246000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.3201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,29]]},"references-count":51,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1002\/brb3.3201"],"URL":"https:\/\/doi.org\/10.1002\/brb3.3201","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/BRB3.3201\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3201\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3201\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3201\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3201\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3201\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3201\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3201\/v1\/decision1","asserted-by":"object"}]},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,29]]},"assertion":[{"value":"2023-04-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e3201"}}