{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:54:21Z","timestamp":1792194861519,"version":"4.4.0"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T00:00:00Z","timestamp":1691366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL142116"],"award-info":[{"award-number":["R01HL142116"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Despite significant improvements in longevity and quality of life associated with antiretroviral therapy, individuals with HIV still suffer from a higher burden of sleep and circadian disruption and inflammatory\u2010based diseases than individuals without HIV. While melatonin is a hormone that has a role in sleep and circadian regulation and has anti\u2010inflammatory properties, the overnight concentration of the urinary melatonin metabolite has not yet been reported in people with HIV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The aim of this study was to compare the overnight urinary melatonin metabolite levels in women aged 35\u201370\u00a0years with HIV (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0151) to a well\u2010matched comparison group of women without HIV (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0147). All women wore a wrist actigraphy monitor and completed daily diaries documenting sleep timing and use of medications and drugs or alcohol for 10\u00a0days. Participants collected their overnight urine near the end of the monitoring period.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Melatonin levels did not differ between women with or without HIV, but more than 40% of women had low levels of melatonin. Higher body mass index predicted lower levels of melatonin, and lower levels of melatonin were associated with lower sleep efficiency as assessed with wrist actigraphy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These data lay the foundation for exploration of the longitudinal consequences of endogenous melatonin levels for inflammatory\u2010based diseases in aging women with and without HIV. Future studies should consider the use of supplemental melatonin to improve sleep in women with lower levels of melatonin.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.3206","type":"journal-article","created":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T09:19:05Z","timestamp":1691399945000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Overnight urinary melatonin levels in women with and without HIV: An observational cohort study"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3816-8194","authenticated-orcid":false,"given":"Helen J.","family":"Burgess","sequence":"first","affiliation":[{"name":"Department of Psychiatry University of Michigan Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen M.","family":"Weber","sequence":"additional","affiliation":[{"name":"Hektoen Institute of Medicine\/CORE Center of Cook County Health Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"Morack","sequence":"additional","affiliation":[{"name":"Hektoen Institute of Medicine\/CORE Center of Cook County Health Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsion","family":"Yohannes","sequence":"additional","affiliation":[{"name":"Hektoen Institute of Medicine\/CORE Center of Cook County Health Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqian","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Population Health Albert Einstein College of Medicine Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaonan","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Population Health Albert Einstein College of Medicine Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Gustafson","sequence":"additional","affiliation":[{"name":"Department of Neurology State University of New York Downstate Health Sciences University Brooklyn New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Medicine Albert Einstein College of Medicine Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Daubert","sequence":"additional","affiliation":[{"name":"Hektoen Institute of Medicine\/CORE Center of Cook County Health Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea C.","family":"Rogando","sequence":"additional","affiliation":[{"name":"Hektoen Institute of Medicine\/CORE Center of Cook County Health Chicago Illinois USA"},{"name":"College of Science and Health Charles R. Drew University of Medicine and Science Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey L.","family":"French","sequence":"additional","affiliation":[{"name":"Department of Medicine Stroger Hospital of Cook County Health Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyy021"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/1574887112666170725132528"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/CDLI.12.9.1013-1019.2005"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2022.101614"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003055"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165\u20101781(89)90047\u20104"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10461\u2010018\u20102308\u2010x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2021.01.034"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033\u20102909.112.1.155"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.10.001"},{"issue":"3","key":"e_1_2_7_12_1","first-page":"780","article-title":"Ethanol inhibits melatonin secretion in healthy volunteers in a dose\u2010dependent randomized double blind cross\u2010over study","volume":"77","author":"Ekman A. 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