{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T14:59:38Z","timestamp":1772117978726,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T00:00:00Z","timestamp":1694995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI18\/00804"],"award-info":[{"award-number":["PI18\/00804"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Therapeutic hypothermia is a promising candidate for stroke treatment although its efficacy has not yet been demonstrated in patients. Changes in blood molecules could act as surrogate markers to evaluate the efficacy and safety of therapeutic cooling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Blood samples from 54 patients included in the EuroHYP\u20101 study (27 treated with hypothermia, and 27 controls) were obtained at baseline, 24\u00a0\u00b1\u00a02\u00a0h, and 72\u00a0\u00b1\u00a04\u00a0h. The levels of a panel of 27 biomarkers, including matrix metalloproteinases and cardiac and inflammatory markers, were measured.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Metalloproteinase\u20103 (MMP\u20103), fatty\u2010acid\u2010binding protein (FABP), and interleukin\u20108 (IL\u20108) increased over time in relation to the hypothermia treatment. Statistically significant correlations between the minimum temperature achieved by each patient in the hypothermia group and the MMP\u20103 level measured at 72\u00a0h, FABP level measured at 24\u00a0h, and IL\u20108 levels measured at 24 and 72\u00a0h were found. No differential biomarker levels were observed in patients with poor or favorable outcomes according to modified Rankin Scale scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although the exact roles of MMP3, FABP, and IL\u20108 in hypothermia\u2010treated stroke patients are not known, further exploration is needed to confirm their roles in brain ischemia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.3230","type":"journal-article","created":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T10:33:52Z","timestamp":1695033232000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Blood biomarker changes following therapeutic hypothermia in ischemic stroke"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1074-990X","authenticated-orcid":false,"given":"Elena","family":"Pal\u00e0","sequence":"first","affiliation":[{"name":"Neurovascular Research Laboratory Vall d'Hebron Institute of Research (VHIR)\u2013Universitat Aut\u00f3noma de Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Penalba","sequence":"additional","affiliation":[{"name":"Neurovascular Research Laboratory Vall d'Hebron Institute of Research (VHIR)\u2013Universitat Aut\u00f3noma de Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Bustamante","sequence":"additional","affiliation":[{"name":"Neurovascular Research Laboratory Vall d'Hebron Institute of Research (VHIR)\u2013Universitat Aut\u00f3noma de Barcelona  Barcelona Spain"},{"name":"Stroke Unit, Hospital Universitari Germans Trias i Pujol  Badalona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Garc\u00eda\u2010Berrocoso","sequence":"additional","affiliation":[{"name":"Neurovascular Research Laboratory Vall d'Hebron Institute of Research (VHIR)\u2013Universitat Aut\u00f3noma de Barcelona  Barcelona Spain"},{"name":"CSIC\/UAB Proteomics Laboratory Institute of Biomedical Research of Barcelona Spanish National Research Council (IIBB\u2010CSIC\/IDIBAPS)  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel","family":"Lamana\u2010Vallverd\u00fa","sequence":"additional","affiliation":[{"name":"Neurovascular Research Laboratory Vall d'Hebron Institute of Research (VHIR)\u2013Universitat Aut\u00f3noma de Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Meisel","sequence":"additional","affiliation":[{"name":"Institute for Medical Immunology Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin  Berlin Germany"},{"name":"Department of Immunology Labor Berlin\u2013Charit\u00e9 Vivantes  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Meisel","sequence":"additional","affiliation":[{"name":"Department of Neurology and Center for Stroke Research Berlin Charit\u00e9 University Hospital Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. 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