{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:02:35Z","timestamp":1772118155613,"version":"3.50.1"},"reference-count":101,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T00:00:00Z","timestamp":1696204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Parents often use sensory stimulation during early\u2010life interactions with infants. These interactions, including gazing, rocking, or singing, scaffold child development. Previous studies have examined infant neural processing during highly controlled sensory stimulus presentation paradigms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>In this study, we investigated infant behavioral and neural responsiveness during a mother\u2013child social interaction during which the mother provided infant stimulation with a progressive increase in the number of sensory modalities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We prospectively collected and analyzed video\u2010coded behavioral interactions and electroencephalogram (EEG) frontal asymmetry (FAS) from infants (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a060) at 2\u20134 months born at \u2265\u00a034\u00a0weeks gestation. As the number of sensory modalities progressively increased during the interaction, infant behaviors of emotional connection in facial expressiveness, sensitivity to mother, and vocal communication increased significantly. Conversely, infant FAS for the entire cohort did not change significantly. However, when we accounted for infant irritability, both video\u2010coded behaviors and EEG FAS markers of infant responsiveness increased across the interaction in the non\u2010irritable infants. The non\u2010irritable infants (49%) demonstrated positive FAS, indicating readiness to engage with, rather than to withdraw from, multisensory but not unisensory interactions with their mothers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>These results suggest that multisensory input from mothers is associated with greater infant neural approach state and highlight the importance of infant behavioral state during neural measures of infant responsiveness.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.3253","type":"journal-article","created":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T01:08:38Z","timestamp":1696295318000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Behavioral and neural measures of infant responsivity increase with maternal multisensory input in non\u2010irritable infants"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3579-9751","authenticated-orcid":false,"given":"Mary Lauren","family":"Neel","sequence":"first","affiliation":[{"name":"Department of Pediatrics &amp; Neonatology Emory University School of Medicine &amp; Children's Healthcare of Atlanta  Atlanta, GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnaud","family":"Jeanvoine","sequence":"additional","affiliation":[{"name":"The Abigail Wexner Research Institute at Nationwide Children's Hospital  Columbus, OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Key","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine  Atlanta, GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann R.","family":"Stark","sequence":"additional","affiliation":[{"name":"Department of Pediatrics &amp; Neonatology Beth Israel Deaconess Medical Center &amp; Harvard Medical School  Boston, MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4023-8051","authenticated-orcid":false,"given":"Elizabeth S.","family":"Norton","sequence":"additional","affiliation":[{"name":"Northwestern University School of Communication  Chicago, IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lance M.","family":"Relland","sequence":"additional","affiliation":[{"name":"The Abigail Wexner Research Institute at Nationwide Children's Hospital  Columbus, OH USA"},{"name":"Department of Anesthesiology &amp; Pain Medicine Nationwide Children's Hospital &amp; The Ohio State University  Columbus, OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krystal","family":"Hay","sequence":"additional","affiliation":[{"name":"The Abigail Wexner Research Institute at Nationwide Children's Hospital  Columbus, OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie L.","family":"Maitre","sequence":"additional","affiliation":[{"name":"Department of Pediatrics &amp; Neonatology Emory University School of Medicine &amp; Children's Healthcare of Atlanta  Atlanta, GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0134549"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2004.03.007"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.2009.21395"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.22178"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0163\u20106383(83)90241\u20102"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1037\/\/0012\u20101649.36.2.190"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0963-7214.2004.00283.x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1037\/dev0000557"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0048577201393174"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/cdev.12008"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2011.01.031"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.10078"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.1580"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/87565641.2018.1433671"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2019.02.013"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2004.03.002"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2005.10.003"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2020.116602"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.150.6.782"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0163\u20106383(82)80021\u20100"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dcn.2017.08.005"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-9280.1992.tb00254.x"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/02699939308409180"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579400004764"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-3514.58.2.330"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7146906"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1037\/\/0021\u2010843x.98.2.127"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1101\/2020.01.29.925271"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/imhj.20025"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rasd.2018.10.001"},{"key":"e_1_2_11_32_1","volume-title":"The neurological assessment of the preterm and full\u2010term newborn infant","author":"Dubowitz L. M.","year":"1999"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.IYC.0000264477.05076.5d"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2021474118"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/1077546308097270"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467\u20109280.2007.02010.x"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-6383(84)80019-3"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1037\/0012-1649.23.2.233"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/1467\u20108624.00262"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.14731"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1177\/0165025419850899"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1332441100"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.infbeh.2013.02.003"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1080\/15295192.2015.1053333"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.14483"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0012855"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.14483"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010020\u20102649\u20102"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532\u20107078.2009.00017.x"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2010.11.041"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00737-006-0148-6"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/cdev.12466"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.20417"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2010.00186"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jecp.2016.02.003"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525\u20101446.1995.tb00006.x"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2011.02.023"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.deafed.a014357"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/infa.12222"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579413000722"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1177\/1754073910387947"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1177\/1754073910390565"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467\u20108624.2008.01204.x"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2009.08.004"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1177\/0165025415576816"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0304\u20103959(97)00034\u20101"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2017.02.036"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10548\u2010020\u201000791\u20104"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1388\u20102457(02)00163\u20103"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1080\/15250000701795655"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2014.08.014"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20763"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.10053"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1037\/dev0000376"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep39019"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469\u20108749.1996.tb12082.x"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2016.05.003"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/cch.12561"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.infbeh.2016.03.003"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.infbeh.2019.101393"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740\u20100929.2012.01014.x"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0193-3973(96)90025-8"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.psych.58.110405.085516"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2017.00430"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2018.10.001"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.21104"},{"issue":"1","key":"e_1_2_11_87_1","first-page":"21","article-title":"Temperament and social behavior in childhood","volume":"40","author":"Rothbart M. K.","year":"1994","journal-title":"Merrill\u2010Palmer Quarterly"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-384982-3.00002-X"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-6383(98)90019-4"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00737\u2010005\u20100074\u2010z"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1017\/s0012162204001434"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpp.12489"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-7687.2004.00344.x"},{"key":"e_1_2_11_94_1","volume-title":"PYTHON 2.6 reference manual","author":"Van Rossum G.","year":"2009"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.22163"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-019-0686-2"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2015.05.016"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0088436"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.infbeh.2013.07.004"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1002\/nur.4770110106"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2014.08.005"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00737\u2010007\u20100191\u2010y"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.3253","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T02:01:02Z","timestamp":1699581662000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.3253"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,2]]},"references-count":101,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1002\/brb3.3253"],"URL":"https:\/\/doi.org\/10.1002\/brb3.3253","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/BRB3.3253\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3253\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3253\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3253\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3253\/v1\/review1","asserted-by":"object"}]},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,2]]},"assertion":[{"value":"2023-02-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e3253"}}