{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:34:53Z","timestamp":1786977293298,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T00:00:00Z","timestamp":1695081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The relationship between restless legs syndrome (RLS) and iron deficiency is a well\u2010known topic. However, the etiology of the disease has not been determined. As the central iron deficiency is the most critical biological abnormality for RLS, we planned a study examining the relationship between RLS and hepcidin, which is the only regulatory hormone of iron metabolism known so far.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>International Restless Legs Syndrome Study Group diagnostic criteria (2014) were taken as a basis. A total of 40 RLS patients and 40 healthy controls were included in the study. To avoid the potential variables that might cause secondary RLS, all the participants were asked to provide hemogram, ferritin, iron, thyroid function tests, and sedimentation analysis. The hepcidin levels were measured with a Human Hepcidin (Hepc 25) ELISA kit (MyBioSource).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The statistically significant results of our analysis show that the red blood cell count, the neutrophil count, the percentage of lymphocytes and neutrophils, and, more distinctively, hepcidin levels were higher in RLS patients in comparison with the control group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this study, no differences were found in iron and ferritin values. High levels of hepcidin, the main regulator of iron metabolism, in those with primary RLS support the possibility that hepcidin may play a role in the pathogenesis of RLS. We think that larger studies on this subject can give clearer ideas.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.3259","type":"journal-article","created":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T00:44:37Z","timestamp":1695170677000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Evaluation of the relationship between idiopathic restless legs syndrome and serum hepcidin levels"],"prefix":"10.1002","volume":"13","author":[{"given":"Semra","family":"Ala\u00e7am K\u00f6ksal","sequence":"first","affiliation":[{"name":"Department of Neurology Kocaeli \u0130zmit SEKA State Hospital  \u0130zmit Kocaeli Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0076-9405","authenticated-orcid":false,"given":"Sena","family":"Boncuk Ula\u015f","sequence":"additional","affiliation":[{"name":"Department of Neurology Ke\u015fan State Hospital  Edirne Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bilgehan At\u0131lgan","family":"Acar","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine Sakarya University  Serdivan Sakarya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T\u00fcrkan","family":"Acar","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine Sakarya University  Serdivan Sakarya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye\u015fim","family":"G\u00fczey Aras","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine Sakarya University  Serdivan Sakarya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"K\u00f6ro\u011flu","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine Sakarya University  Serdivan Sakarya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsmc.2015.05.022"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.56.2.263"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1303646"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2014.03.025"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.1062"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102005\u201007\u20103046"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201068851\u20100"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsmc.2015.05.021"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2006.04.008"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr012"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27287"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0b013e328365ab07"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2021.10.008"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102011\u201002\u2010337907"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9124115"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2022.101744"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.4149\/BLL_2023_006"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.16\u20104\u2010379"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0014\u20105793(00)01920\u20107"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010021\u201000311\u2010z"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102869.2004.00403.x"},{"issue":"7","key":"e_1_2_8_23_1","first-page":"160","article-title":"Restless legs","volume":"17","author":"Nordlander N. 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