{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:01:57Z","timestamp":1772118117473,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:00:00Z","timestamp":1697500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Patients with a single subcortical infarction (SSI) in the territory of the middle cerebral artery (MCA) often experience early neurological deterioration (END) despite receiving intravenous thrombolytic therapy (IVT). In this study, predictors of END were investigated in patients with SSI in the MCA after IVT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with SSI in the MCA territory who had received IVT between June 2020 and 2022 were included. END was defined as an increase in the total National Institutes of Health Stroke Scale (NIHSS) score by \u22652 or in the motor NIHSS score by \u22651 within the first 72\u00a0h of admission. Patients with proximal (pSSI) and distal SSI (dSSI) were analyzed to determine SSI type\u2010specific predictors for END.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We evaluated 174 patients with SSI in the MCA territory who underwent IVT. Multivariable logistic regression analysis showed that pSSI (odds ratio [OR]\u00a0=\u00a00.242; 95% confidence interval [CI], 0.104\u20130.564;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.001), lower high\u2010density lipoprotein cholesterol (HDL\u2010C) (OR\u00a0=\u00a00.150; 95% CI, 0.033\u20130.682;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.014), higher blood glucose (OR\u00a0=\u00a00.858; 95% CI, 0.752\u20130.979;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.023), and higher red blood cells count (OR\u00a0=\u00a01.966; 95% CI, 1.154\u20133.349;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.013) were risk factors for END. In patients with pSSI, HDL\u2010C and blood glucose were associated with END. No variable related to END was found in the dSSI group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The proportion of END in patients with SSI in the MCA territory after IVT was not low; therefore, pSSI, HDL\u2010C, blood glucose, and red blood cells should be monitored closely. The frequency and predictors of SSI in the MCA territory differed between pSSI and dSSI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.3283","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T02:44:54Z","timestamp":1697597094000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Predictive factors for early neurological deterioration after intravenous thrombolysis of single subcortical infarction in the territory of the middle cerebral artery"],"prefix":"10.1002","volume":"13","author":[{"given":"Meng","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Neurology Zhengzhou People's Hospital  Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4901-1697","authenticated-orcid":false,"given":"Xuemin","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of 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