{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:15:54Z","timestamp":1791396954361,"version":"4.3.3"},"reference-count":51,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,3,11]],"date-time":"2015-03-11T00:00:00Z","timestamp":1426032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Purpose<\/jats:title><jats:p>Accurate diagnosis of Atypical Parkinsonian Syndromes (<jats:styled-content style=\"fixed-case\">APS<\/jats:styled-content>) is important due to differences in prognosis and management, but remains a challenge in the clinical setting. The purpose of our meta\u2010analysis was to identify characteristic patterns of gray matter atrophy in Corticobasal Degeneration (<jats:styled-content style=\"fixed-case\">CBD<\/jats:styled-content>), Progressive Supranuclear Palsy (<jats:styled-content style=\"fixed-case\">PSP<\/jats:styled-content>), Multisystem\u2010Atrophy Parkinsonian type (<jats:styled-content style=\"fixed-case\">MSA<\/jats:styled-content>\u2010P), and Idiopathic Parkinson's Disease (<jats:styled-content style=\"fixed-case\">IPD<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Whole\u2010brain meta\u2010analysis was performed on 39 published voxel\u2010based morphometry (<jats:styled-content style=\"fixed-case\">VBM<\/jats:styled-content>) articles (consisting of 404 <jats:styled-content style=\"fixed-case\">IPD<\/jats:styled-content>, 87 <jats:styled-content style=\"fixed-case\">MSA<\/jats:styled-content>\u2010P, 165 <jats:styled-content style=\"fixed-case\">CBD<\/jats:styled-content>, and 176 <jats:styled-content style=\"fixed-case\">PSP<\/jats:styled-content> subjects) using the modified Anatomic Likelihood Estimation method. Based on these results, contrast analyses were then utilized to determine areas of atrophy shared by as well as unique to each disorder.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CBD<\/jats:styled-content> was characterized by asymmetric gray matter atrophy in multiple cortical regions, while the thalamus\u2010midbrain and insula were predominantly involved in <jats:styled-content style=\"fixed-case\">PSP<\/jats:styled-content>. The striatum and superior cerebellum were affected in <jats:styled-content style=\"fixed-case\">MSA<\/jats:styled-content>\u2010P, while <jats:styled-content style=\"fixed-case\">IPD<\/jats:styled-content> demonstrated an anterior cerebral pattern. Although there was a mild overlap among <jats:styled-content style=\"fixed-case\">PSP<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> CBD<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">MSA<\/jats:styled-content>\u2010P, significant regions of atrophy unique to each disorder were identified, including (1) the superior parietal lobule in <jats:styled-content style=\"fixed-case\">CBD<\/jats:styled-content> (2) putamen in <jats:styled-content style=\"fixed-case\">MSA<\/jats:styled-content>\u2010P (3) insula and medial dorsal nucleus in <jats:styled-content style=\"fixed-case\">PSP<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggest that there are characteristic patterns of atrophy in <jats:styled-content style=\"fixed-case\">APS<\/jats:styled-content>. Guided by these findings, future studies on the individual subject level may lead to the development of robust imaging biomarkers.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.329","type":"journal-article","created":{"date-parts":[[2015,3,12]],"date-time":"2015-03-12T04:43:39Z","timestamp":1426135419000},"source":"Crossref","is-referenced-by-count":45,"title":["Patterns of gray matter atrophy in atypical parkinsonism syndromes: a VBM meta\u2010analysis"],"prefix":"10.1002","volume":"5","author":[{"given":"Fang","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Radiology University of Texas Health Science Center San Antonio Texas"},{"name":"Research Imaging Institute San Antonio Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel S.","family":"Barron","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Texas Health Science Center San Antonio Texas"},{"name":"Research Imaging Institute San Antonio Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bundhit","family":"Tantiwongkosi","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Texas Health Science Center San Antonio Texas"},{"name":"Research Imaging Institute San Antonio Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Fox","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Texas Health Science Center San Antonio Texas"},{"name":"Research Imaging Institute San Antonio Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2000.0582"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2013.07.004"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2012.11.004"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12637"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2014.08.002"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23766"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.65.6.796"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.1.81"},{"key":"e_1_2_7_10_1","first-page":"419","article-title":"Multiple system atrophy: cellular and molecular pathology","volume":"54","author":"Burn D. 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