{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T14:03:58Z","timestamp":1756994638527,"version":"3.41.2"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,1,28]],"date-time":"2024-01-28T00:00:00Z","timestamp":1706400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH118278","R01MH119084","R01MH120170","R01MH124871"],"award-info":[{"award-number":["R01MH118278","R01MH119084","R01MH120170","R01MH124871"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["K01AA025113"],"award-info":[{"award-number":["K01AA025113"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"publisher","award":["R276\u20102018\u20104581"],"award-info":[{"award-number":["R276\u20102018\u20104581"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000874","name":"Brain and Behavior Research Foundation","doi-asserted-by":"publisher","award":["Distinguished Investigator Grant"],"award-info":[{"award-number":["Distinguished Investigator Grant"]}],"id":[{"id":"10.13039\/100000874","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Cardiovascular complications occur in up to 80% of patients with anorexia nervosa (AN), yet the underlying mechanisms warrant further investigation. We assessed the genetic correlation (<jats:italic>r<jats:sub>g<\/jats:sub><\/jats:italic>) between AN and cardiovascular disease (CVD) events to inform whether elevated cardiovascular risk among individuals with AN is due to shared genetic effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We used genome\u2010wide association study summary statistics for AN (<jats:italic>N<\/jats:italic>\u00a0=\u00a072,517), AN with binge eating (<jats:italic>N<\/jats:italic>\u00a0=\u00a012,630), AN without binge eating (<jats:italic>N<\/jats:italic>\u00a0=\u00a012,516), and six CVD events (<jats:italic>N<\/jats:italic>\u00a0=\u00a0390,142 to 977,323). We calculated the <jats:italic>r<jats:sub>g<\/jats:sub><\/jats:italic>s via linkage disequilibrium score regression and corrected for multiple testing using false discovery rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant <jats:italic>r<jats:sub>g<\/jats:sub><\/jats:italic>s emerged between AN with heart failure (<jats:italic>r<jats:sub>g<\/jats:sub><\/jats:italic>\u00a0=\u00a0\u20130.11, SE\u00a0=\u00a00.05, <jats:italic>q<\/jats:italic>\u00a0=\u00a0.04) and myocardial infarction (<jats:italic>r<jats:sub>g<\/jats:sub><\/jats:italic>\u00a0=\u00a0\u20130.10, SE\u00a0=\u00a00.03, <jats:italic>q<\/jats:italic>\u00a0=\u00a0.01). AN with binge eating had a significant <jats:italic>r<jats:sub>g<\/jats:sub><\/jats:italic> with myocardial infarction (<jats:italic>r<jats:sub>g<\/jats:sub><\/jats:italic>\u00a0=\u00a0\u20130.15, SE\u00a0=\u00a00.06, <jats:italic>q<\/jats:italic>\u00a0=\u00a0.02). No significant <jats:italic>r<jats:sub>g<\/jats:sub><\/jats:italic> emerged between AN without binge eating and any CVD event.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Some loci affect the liability to AN and CVD in opposite directions and the shared genetic effects may not be consistent across all CVD events. Our results provide further evidence suggesting that the elevated cardiovascular risk in AN may not be due to shared genetic underpinnings, but more likely a downstream consequence of the disease.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.3294","type":"journal-article","created":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T06:40:07Z","timestamp":1706510407000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Shared genetic risk between anorexia nervosa and cardiovascular disease events: Evidence from genome\u2010wide association studies"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0768-7055","authenticated-orcid":false,"given":"Baiyu","family":"Qi","sequence":"first","affiliation":[{"name":"Department of Epidemiology University of North Carolina at Chapel Hill  Chapel Hill North Carolina US"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariaelisa","family":"Graff","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of North Carolina at Chapel Hill  Chapel Hill North Carolina US"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Eating Disorders Working Group of the Psychiatric Genomics C","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia M","family":"Bulik","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of North Carolina at Chapel Hill  Chapel Hill North Carolina US"},{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Nutrition University of North Carolina at Chapel Hill  Chapel Hill North Carolina US"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kari E","family":"North","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of North Carolina at Chapel Hill  Chapel Hill North Carolina US"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9368-9457","authenticated-orcid":false,"given":"Melissa A","family":"Munn\u2010Chernoff","sequence":"additional","affiliation":[{"name":"Department of Community, Family, and Addiction Sciences Texas Tech University  Lubbock Texas US"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.035774"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166\u20104328(01)00297\u20102"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3406"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3211"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11739\u2010014\u20101107\u20102"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2017.16121402"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu5125140"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40519\u2010018\u20100567\u20101"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa1040"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.23481"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2010.29203"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.114.001285"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010018\u20100058\u20103"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1353\/book.98249"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.23664"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22389"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.114.001193"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010018\u20100133\u20109"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22481"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21197302"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201013690\u20105"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1017\/S104795111500267X"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22624"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.312086"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010019\u20100439\u20102"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.3294","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T13:52:55Z","timestamp":1711547575000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.3294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,28]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1002\/brb3.3294"],"URL":"https:\/\/doi.org\/10.1002\/brb3.3294","archive":["Portico"],"relation":{},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"type":"print","value":"2162-3279"},{"type":"electronic","value":"2162-3279"}],"subject":[],"published":{"date-parts":[[2024,1,28]]},"assertion":[{"value":"2023-09-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e3294"}}