{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T15:47:00Z","timestamp":1791820020149,"version":"4.3.4"},"reference-count":71,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T00:00:00Z","timestamp":1700438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018488","name":"Clinical and Translational Science Institute, University of Florida","doi-asserted-by":"publisher","award":["UL1TR001427"],"award-info":[{"award-number":["UL1TR001427"]}],"id":[{"id":"10.13039\/100018488","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019192","name":"Center for Clinical and Translational Science, University of Alabama at Birmingham","doi-asserted-by":"publisher","award":["UL1TR001417"],"award-info":[{"award-number":["UL1TR001417"]}],"id":[{"id":"10.13039\/100019192","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R01AG054370"],"award-info":[{"award-number":["R01AG054370"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 TR000064"],"award-info":[{"award-number":["UL1 TR000064"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R37AG033906"],"award-info":[{"award-number":["R37AG033906"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5K02AG062498"],"award-info":[{"award-number":["5K02AG062498"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Introduction: Previous research indicates ethnic\/race group differences in pain and neurodegenerative diseases. Accounting for socioenvironmental factors reduces ethnic\/race group differences in clinical and experimental pain. In the current study sample, we previously reported that in individuals with knee pain, ethnic\/race group differences were observed in bilateral temporal lobe thickness, areas of the brain associated with risk for Alzheimer's disease, and related dementias. The purpose of the study was to determine if socioenvironmental factors reduce or account for previously observed ethnic\/race group differences and explore if a combined effect of socioenvironmental risk and chronic pain severity on temporal lobe cortices is evident.<\/jats:p>\n                  <jats:p>\n                    Methods: Consistent with the prior study, the sample was comprised of 147 adults (95 women, 52 men), 45\u201385 years of age, who self\u2010identified as non\u2010Hispanic Black (\n                    <jats:italic>n<\/jats:italic>\n                    =\u00a072) and non\u2010Hispanic White (\n                    <jats:italic>n<\/jats:italic>\n                    =\u00a075), with knee pain with\/at risk for osteoarthritis. Measures included demographics, health history, pain questionnaires, cognitive screening, body mass index, individual\u2010 and community\u2010level socioenvironmental factors (education, income, household size, marital and insurance status, and area deprivation index), and brain imaging. We computed a summative socioenvironmental risk index. Results: Regression analyses showed that with the inclusion of socioenvironmental factors, the model was significant (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a0.001), and sociodemographic (ethnic\/race) group differences were not significant (\n                    <jats:italic>p =<\/jats:italic>\n                    .118). Additionally, findings revealed an additive stress load pattern indicating thinner temporal lobe cortices with greater socioenvironmental risk and chronic pain severity (\n                    <jats:italic>p =<\/jats:italic>\n                    .048).\n                  <\/jats:p>\n                  <jats:p>Implications: Although individual socioenvironmental factors were not independent predictors, when collectively combined in models, ethnic\/race group differences in bilateral temporal lobe structures were not replicated. Further, combined socioenvironmental risk factors and higher chronic pain severity were associated with thinner bilateral temporal lobes.<\/jats:p>","DOI":"10.1002\/brb3.3330","type":"journal-article","created":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T17:16:37Z","timestamp":1700586997000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Greater socioenvironmental risk factors and higher chronic pain stage are associated with thinner bilateral temporal lobes"],"prefix":"10.1002","volume":"13","author":[{"given":"Lisa H.","family":"Antoine","sequence":"first","affiliation":[{"name":"Department of Psychology University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared J.","family":"Tanner","sequence":"additional","affiliation":[{"name":"Department of Clinical and Health Psychology University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9175-5342","authenticated-orcid":false,"given":"Angela M.","family":"Mickle","sequence":"additional","affiliation":[{"name":"Pain Research &amp; 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Finance North Carolina A&amp;T State University  Greensboro North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas W.","family":"Buford","sequence":"additional","affiliation":[{"name":"Department of Medicine \u2212 Division of Gerontology, Geriatrics, and Palliative Care University of Alabama at Birmingham  Birmingham Alabama USA"},{"name":"Birmingham\/Atlanta Geriatric Research, Education, and Clinical Center Birmingham VA Medical Center  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin N.","family":"Aroke","sequence":"additional","affiliation":[{"name":"School of Nursing University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David T.","family":"Redden","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger B.","family":"Fillingim","sequence":"additional","affiliation":[{"name":"Pain Research &amp; 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