{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:31:47Z","timestamp":1786977107522,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T00:00:00Z","timestamp":1704931200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Neuroimaging studies have revealed the role of the right dorsolateral prefrontal cortex (DLPFC) in the neurobiological mechanism of obsessive\u2013compulsive disorder (OCD). However, only a few studies have examined the functional connectivity (FC) pattern of the right DLPFC at rest in OCD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this research is to examine the FC patterns of the right DLPFC at rest in OCD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty\u2010eight medication\u2010free patients with OCD and 20 healthy controls underwent resting\u2010state functional magnetic resonance imaging. Seed\u2010based FC and support vector machine (SVM) were used to analyze the imaging data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The patients with OCD showed reduced FC values in the right middle temporal gyrus (MTG), right superior temporal gyrus, right ventral anterior cingulate cortex (vACC), and left Crus II. No brain regions showed a remarkable difference in FC values in patients with OCD after 8 weeks of medication treatment. The reduced right DLPFC\u2013right MTG and right DLPFC\u2013right vACC connectivities were correlated with the clinical symptoms of OCD. SVM results showed that reduced right DLPFC\u2013right MTG connectivity at rest could predict the therapeutic response to OCD medication.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The findings highlight the important role of the right DLPFC in the pathophysiological mechanism of OCD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.3333","type":"journal-article","created":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T22:39:30Z","timestamp":1705012770000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Reduced functional connectivity of the right dorsolateral prefrontal cortex at rest in obsessive\u2013compulsive disorder"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9109-6172","authenticated-orcid":false,"given":"Zhaoxi","family":"Zhong","sequence":"first","affiliation":[{"name":"Henan Key Laboratory of Biological Psychiatry The Second Affiliated Hospital of Xinxiang Medical University  Xinxiang Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangpan","family":"Ou","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Mental Disorders and Department of Psychiatry The Second Xiangya Hospital of Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunhui","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Qiqihar Medical University  Qiqihar Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3241-3091","authenticated-orcid":false,"given":"Ping","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Qiqihar Medical University  Qiqihar Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Shi","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Biological Psychiatry The Second Affiliated Hospital of Xinxiang Medical University  Xinxiang Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Qiqihar Medical University  Qiqihar Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuicui","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Qiqihar Medical University  Qiqihar Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tinghuizi","family":"Shang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Qiqihar Medical University  Qiqihar Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Qiqihar Medical University  Qiqihar Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiology The Second Xiangya Hospital of Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Wang","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Mental Disorders and Department of Psychiatry The Second Xiangya Hospital of Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Guo","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Mental Disorders and Department of Psychiatry The Second Xiangya Hospital of Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3963-660X","authenticated-orcid":false,"given":"Luxian","family":"Lv","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Biological Psychiatry The Second Affiliated Hospital of Xinxiang Medical University  Xinxiang Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,11]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1234733"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2012.09.002"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2018.12.019"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1364-6613(00)01483-2"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcn.12419"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2019.03.008"},{"issue":"5","key":"e_1_2_14_8_1","first-page":"135","article-title":"Usefulness of the reliable change index for psychology and psychiatry in clinical practice: A case report of cognitive\u2010behavioral therapy","volume":"12","author":"Costa D. D. S.","year":"2015","journal-title":"Clinical Neuropsychiatry"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2020.00098"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2016.08.027"},{"key":"e_1_2_14_11_1","volume-title":"Structured clinical interview for DSM\u2010IV Axis I disorders, clinician version (SCID\u2010CV)","author":"First M. B.","year":"1996"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0604187103"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1503\/Jpn.130220"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2017.04.012"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(98)00158-1"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1109\/EMBC.2018.8512490"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2007.09.005"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2016.0700"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1017\/neu.2016.48"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajp.2012.07.004"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0067262"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2017.01.024"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2008.94"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.4088\/jcp.v62n1211"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandc.2015.12.004"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2019.08.019"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291718001915"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888\u2010019\u20102184\u20106"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2019.00452"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2015.07.048"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2018.11.009"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2017.03.033"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.3333","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T06:38:05Z","timestamp":1710311885000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.3333"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1002\/brb3.3333"],"URL":"https:\/\/doi.org\/10.1002\/brb3.3333","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/BRB3.3333\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3333\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3333\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3333\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3333\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3333\/v4\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3333\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3333\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3333\/v4\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3333\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/BRB3.3333\/v2\/response1","asserted-by":"object"}]},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"2023-04-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e3333"}}