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Our aim is to characterize temporal impulsivity in HD and to disentangle the white matter correlate associated with impulsivity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forty\u2010seven HD individuals and 36 healthy controls were scanned and evaluated for temporal impulsivity using a delay\u2010discounting (DD) task and complementary Sensitivity to Punishment and Sensitivity to Reward Questionnaire. Diffusion tensor imaging was employed to characterize the structural connectivity of three limbic tracts: the uncinate fasciculus (UF), the accumbofrontal tract (NAcc\u2010OFC), and the dorsolateral prefrontal cortex connectig the caudate nucleus (DLPFC\u2010cn). Multiple linear regression analyses were applied to analyze the relationship between impulsive behavior and white matter microstructural integrity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our results revealed altered structural connectivity in the DLPC\u2010cn, the NAcc\u2010OFC and the UF in HD individuals. At the same time, the variability in structural connectivity of these tracts was associated with the individual differences in temporal impulsivity. Specifically, increased structural connectivity in the right NAcc\u2010OFC and reduced connectivity in the left UF were associated with higher temporal impulsivity scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The present findings highlight the importance of investigating the spectrum of temporal impulsivity in HD. As, while less prevalent than other psychiatric features, this symptom is still reported to significantly impact the quality of life of patients and caregivers. This study provides evidence that individual differences observed in temporal impulsivity may be explained by variability in limbic frontostriatal tracts, while shedding light on the role of sensitivity to reward in modulating impulsive behavior through the selection of immediate rewards.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.3335","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T05:52:22Z","timestamp":1709790742000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Disentangling the neurobiological bases of temporal impulsivity in Huntington's disease"],"prefix":"10.1002","volume":"14","author":[{"given":"Helena","family":"Pardina\u2010Torner","sequence":"first","affiliation":[{"name":"Cognition and Brain Plasticity Unit Bellvitge Biomedical Research Institute (IDIBELL)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1988-5916","authenticated-orcid":false,"given":"Audrey E.","family":"De Paepe","sequence":"additional","affiliation":[{"name":"Cognition and Brain Plasticity Unit Bellvitge Biomedical Research Institute (IDIBELL)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Garcia\u2010Gorro","sequence":"additional","affiliation":[{"name":"Cognition and Brain Plasticity Unit Bellvitge Biomedical Research Institute (IDIBELL)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Rodriguez\u2010Dechicha","sequence":"additional","affiliation":[{"name":"Hestia Duran i Reynals Hospital Duran i Reynals, Hospitalet de Llobregat  Barcelona Spain"},{"name":"Departament de Psicologia Cl\u00ednica i de la Salut Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Vaquer","sequence":"additional","affiliation":[{"name":"Hestia Duran i Reynals Hospital Duran i Reynals, Hospitalet de Llobregat  Barcelona Spain"},{"name":"Departament de Psicologia Cl\u00ednica i de la Salut Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matilde","family":"Calopa","sequence":"additional","affiliation":[{"name":"Movement Disorders Unit, Neurology Service Hospital Universitari de Bellvitge  Barcelona Spain"},{"name":"ICREA (Catalan Institute for Research and Advanced Studies)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesus","family":"Ruiz\u2010Idiago","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Forensic Medicine Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"Hospital Mare de Deu de la Merc\u00e8  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celia","family":"Mareca","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Forensic Medicine Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"Hospital Mare de Deu de la Merc\u00e8  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2357-5195","authenticated-orcid":false,"given":"Ruth","family":"de Diego\u2010Balaguer","sequence":"additional","affiliation":[{"name":"Cognition and Brain Plasticity Unit Bellvitge Biomedical Research Institute (IDIBELL)  Barcelona Spain"},{"name":"Department of Cognition, Development and Education Psychology Universitat de Barcelona  Barcelona Spain"},{"name":"Institute of Neurosciences Universitat de Barcelona  Barcelona Spain"},{"name":"ICREA (Catalan Institute for Research and Advanced Studies)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3879-0496","authenticated-orcid":false,"given":"Estela","family":"Camara","sequence":"additional","affiliation":[{"name":"Cognition and Brain Plasticity Unit Bellvitge Biomedical Research Institute (IDIBELL)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3459\u201015.2016"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ane.12728"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0376\u20106357(03)00150\u20105"},{"key":"e_1_2_9_5_1","unstructured":"Andersson J. 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