{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T10:25:53Z","timestamp":1773311153654,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T00:00:00Z","timestamp":1704153600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020844","name":"Interuniversitair Micro-Electronica Centrum VZW","doi-asserted-by":"publisher","award":["Context\u2010aware health monitoring project"],"award-info":[{"award-number":["Context\u2010aware health monitoring project"]}],"id":[{"id":"10.13039\/100020844","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003441","name":"Universitair Ziekenhuis Gent","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003441","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["Jonas Van Der Donckt (1S56322N)"],"award-info":[{"award-number":["Jonas Van Der Donckt (1S56322N)"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the changes in activity energy expenditure (AEE) throughout daytime cluster headache (CH) attacks in patients with chronic CH and to evaluate the usefulness of actigraphy as a digital biomarker of CH attacks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>CH is a primary headache disorder characterized by attacks of severe to very severe unilateral pain (orbital, supraorbital, temporal, or in any combination of these sites), with ipsilateral cranial autonomic symptoms and\/or a sense of restlessness or agitation. We hypothesized increased AEE from hyperactivity during attacks measured by actigraphy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An observational study including patients with chronic CH was conducted. During 21 days, patients wore an actigraphy device on the nondominant wrist and recorded CH attack\u2010related data in a dedicated smartphone application. Accelerometer data were used for the calculation of AEE before and during daytime CH attacks that occurred in ambulatory settings, and without restrictions on acute and preventive headache treatment. We compared the activity and movements during the pre\u2010ictal, ictal, and postictal phases with data from wrist\u2010worn actigraphy with time\u2010concordant intervals during non\u2010headache periods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Four patients provided 34 attacks, of which 15 attacks met the eligibility criteria for further analysis. In contrast with the initial hypothesis of increased energy expenditure during CH attacks, a decrease in movement was observed during the pre\u2010ictal phase (30\u00a0min before onset to onset) and during the headache phase. A significant decrease (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.01) in the proportion of high\u2010intensity movement during headache attacks, of which the majority were oxygen\u2010treated, was observed. This trend was less present for low\u2010intensity movements.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The unexpected decrease in AEE during the pre\u2010ictal and headache phase of daytime CH attacks in patients with chronic CH under acute and preventive treatment in ambulatory settings has important implications for future research on wrist actigraphy in CH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.3360","type":"journal-article","created":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T22:55:06Z","timestamp":1704236106000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Patients with chronic cluster headache may show reduced activity energy expenditure on ambulatory wrist actigraphy recordings during daytime attacks"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8400-1163","authenticated-orcid":false,"given":"Nicolas","family":"Vandenbussche","sequence":"first","affiliation":[{"name":"Department of Neurology Ghent University Hospital  Ghent Belgium"},{"name":"Department of Basic and Applied Medical Sciences, Faculty of Medicine and Health Sciences Ghent University  Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonas","family":"Van Der Donckt","sequence":"additional","affiliation":[{"name":"IDLab, Ghent University\u2014imec  Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathias","family":"De Brouwer","sequence":"additional","affiliation":[{"name":"IDLab, Ghent University\u2014imec  Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bram","family":"Steenwinckel","sequence":"additional","affiliation":[{"name":"IDLab, Ghent University\u2014imec  Ghent 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