{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:34:17Z","timestamp":1786977257688,"version":"build-2736575974"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T00:00:00Z","timestamp":1704153600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31970979"],"award-info":[{"award-number":["31970979"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82090034"],"award-info":[{"award-number":["82090034"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["821001498"],"award-info":[{"award-number":["821001498"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to explore decision\u2010making impulsivity and its neural mechanisms in patients with episodic migraine without aura (EMoA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Previous evidence indicates increased impulsivity and altered reward processing in patients with chronic migraine and medication overuse; however, whether the same holds true for those with EMoA is unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Patients newly diagnosed with EMoA (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a051) and healthy controls (HC,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a045) were recruited. All participants completed delay discounting task, cognitive assessments, a questionnaire for headache profile, and resting\u2010state function magnetic resonance imaging scans. Resting\u2010state functional connectivity (RSFC) between the regions of interest and the entire brain was explored.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients with EMoA showed a steeper subjective discount rate than HCs (\n                      <jats:italic>F<\/jats:italic>\n                      \u00a0=\u00a04.74,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.032), which was positively related to a history of migraines (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0.742,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.001). RSFC among the ventral striatum (vSTR), ventromedial prefrontal cortex, and occipital cortex was lower in patients with EMoA than in control groups, which was correlated with history (\n                      <jats:italic>r<\/jats:italic>\n                      \u2032\u00a0=\u00a0.294,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.036) and subjective discount rate (\n                      <jats:italic>r<\/jats:italic>\n                      \u2032\u00a0=\u00a0.380,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.006). Additionally, discounting rates and RSFC between the vSTR and occipital regions were significantly abnormal in the triptan group than the non\u2010triptan group. Mediating effect analysis indicated a significant mediating effect in the change in RSFC between the vSTR and occipital status, history of triptan use, and subjective discount rate.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study further elucidated that an increase in delayed discounting rate exists in patients with EMoA and is related to the abnormality of the value processing network.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.3367","type":"journal-article","created":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T22:58:38Z","timestamp":1704236318000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Patients with episodic migraine without aura have an increased rate of delayed discounting"],"prefix":"10.1002","volume":"14","author":[{"given":"Lu","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital of Anhui Medical University  Hefei China"},{"name":"Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders  Hefei China"},{"name":"Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyang","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital of Anhui Medical University  Hefei China"},{"name":"Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders  Hefei China"},{"name":"Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9353-0849","authenticated-orcid":false,"given":"Manman","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital of Anhui Medical University  Hefei China"},{"name":"Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Geng","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital of Anhui Medical University  Hefei China"},{"name":"Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panpan","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital of Anhui Medical University  Hefei China"},{"name":"Anhui Province Key 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Hefei China"},{"name":"Institute of Artificial Intelligence Hefei Comprehensive National Science Center  Hefei China"},{"name":"Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders  Hefei China"},{"name":"Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health  Hefei 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