{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T10:38:15Z","timestamp":1788950295317,"version":"build-2803163510"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,6]],"date-time":"2024-01-06T00:00:00Z","timestamp":1704499200000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The motor symptoms (MS) of Parkinson's disease (PD) have been affecting the quality of life in patients. In clinical practice, most patients with PD report that MS are more severe in winter than in summer, and hyperthermic baths (HTB) could temporarily improve MS. The study aimed to evaluate the effects of seasonal variation and aquatic thermal environment of HTB on the MS of PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>A cross\u2010sectional study of 203 Chinese Han patients was performed. Univariate and multivariate analyses were performed to analyze seasonal variation in MS relative to baseline data (sex, age at onset, duration, season of birth, Hoehn and Yahr stage, family history, levodopa equivalent dose, and the effect of HTB on MS). Ten subjects participated in the HTB study, and one patient dropped out. The paired Wilcoxon rank test was used to assess the differences in the Movement Disorder Society\u2010United Parkinson's disease Rating Scale (MDS\u2010UPDRS) part III motor examination total scores and the modified Webster Symptoms Score between non\u2010HTB and before HTB and between non\u2010HTB and after HTB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The improvement of MS after HTB was an independent risk factor for seasonal variation in MS (OR, 25.203; 95% CI, 10.951\u201358.006;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u00a0.000). Patients with PD had significant improvements in the MDS\u2010UPDRS part III motor examination total scores, especially in bradykinesia (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u00a0.043), rigidity (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u00a0.008), posture (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u00a0.038), and rest tremor amplitude (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u00a0.047).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Seasonal variation in temperature and water temperature of HTB may affect MS in some patients with PD. Simple HTB could be recommended as physiotherapy for patients with PD who report temperature\u2010sensitive MS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.3369","type":"journal-article","created":{"date-parts":[[2024,1,6]],"date-time":"2024-01-06T11:50:37Z","timestamp":1704541837000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Motor symptoms of Parkinson's disease are affected by temperature: A controlled pilot study"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7540-274X","authenticated-orcid":false,"given":"Ting","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Neurology, Nanjing First Hospital Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi\u2010Xi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Nanjing First Hospital Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen\u2010Yu","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Affiliated Zhongda Hospital, School of Medicine, Institute of Neuropsychiatry, Key Laboratory of Developmental Genes and Human Disease Southeast University  Nanjing China"},{"name":"Department of Mental Health and Public Health, Faculty of Life and Health Sciences, Shenzhen Institute of Advanced Technology Chinese Academy of Sciences  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Ying","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Nanjing First Hospital Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong\u2010Rong","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Nanjing First Hospital Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui\u2010Hui","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Nanjing First Hospital Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9338-4346","authenticated-orcid":false,"given":"You\u2010Yong","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Neurology, Nanjing First Hospital Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying\u2010Dong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Nanjing First Hospital Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph16071280"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1734\u20101140(10)70242\u20105"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010010\u20100664\u20103"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296\u2010004\u20100487\u20104"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2016.01.001"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0894-1130(00)80019-8"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.23.4.283"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1953\u201010.2010"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296\u2010010\u20101628\u20106"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbmt.2018.01.012"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00435.2005"},{"key":"e_1_2_10_13_1","first-page":"43","article-title":"Experimental study on the usability of residential hot water supply system. 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