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This study aimed to evaluate the changes in brain metabolism in patients with HL and different types of dementia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with cognitive impairment (CI) and HL treated at the university\u2010based memory clinic from May 2016 to October 2021 were included. In total, 108 patients with CI and HL prospectively underwent audiometry, neuropsychological test, magnetic resonance imaging, and <jats:sup>18<\/jats:sup>F\u2010fluorodeoxyglucose positron emission tomography. Twenty\u2010seven individuals without cognitive impairment and hearing loss were enrolled as a control group. Multivariable regression was performed to evaluate brain regions correlated with each pathology type after adjusting for confounding factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Multivariable regression analyses revealed that Alzheimer's disease\u2010related CI (ADCI) was associated with hypometabolic changes in the right superior temporal gyrus (STG), right middle temporal gyrus (MTG), and bilateral medial temporal lobe. Lewy body disease\u2010related CI (LBDCI) and vascular CI were associated with hypermetabolic and hypometabolic changes in the ascending auditory pathway, respectively. In the pure ADCI group, the degree of HL was positively associated with abnormal increase of brain metabolism in the right MTG, whereas it was negatively associated with decreased brain metabolism in the right STG in the pure LBDCI group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Each dementia type is associated with distinct changes in brain metabolism in patients with HL.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.3374","type":"journal-article","created":{"date-parts":[[2024,1,6]],"date-time":"2024-01-06T16:59:55Z","timestamp":1704560395000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Distinct changes in brain metabolism in patients with dementia and hearing loss"],"prefix":"10.1002","volume":"14","author":[{"given":"Ji Hyuk","family":"Han","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangwon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Hoon","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mijin","family":"Yun","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung Seok","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Neurology Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1906-6969","authenticated-orcid":false,"given":"Jinsei","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Yonsei University College of Medicine  Seoul Republic of Korea"},{"name":"Graduate School of Medical Science Yonsei University College of Medicine  Seoul Republic of Korea"},{"name":"Brain Korea 21 Project Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097\u20100193(1999)7:4<254::AID\u2010HBM4>3.0.CO;2\u2010G"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/10.5.512"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910\u2010017\u20100764\u20108"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010016\u20100198\u20106"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000010575"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010021\u201000811\u2010w"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(14)70090\u20100"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31826e263d"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.51.6.745"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2020.08.003"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11065\u2010016\u20109334\u20100"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/089198870201500402"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2021.17.2.290"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000007373"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600296"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012372560-8\/50008-5"},{"issue":"9","key":"e_1_2_9_18_1","first-page":"1435","article-title":"PET evidence of neuroplasticity in adult auditory cortex of postlingual deafness","volume":"44","author":"Lee J. 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