{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:05:36Z","timestamp":1753862736245,"version":"3.41.2"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T00:00:00Z","timestamp":1705449600000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["ZYGX2022YGRH017"],"award-info":[{"award-number":["ZYGX2022YGRH017"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071320","82271328","82371322"],"award-info":[{"award-number":["82071320","82271328","82371322"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Neuro\u2010ophthalmologic symptoms and retinal changes have been increasingly observed following thalamic stroke, and there is mounting evidence indicating distinct alterations occurring in the vision\u2010related functional network. However, the intrinsic correlations between these changes are not yet fully understood. Our objective was to explore the altered patterns of functional network connectivity and retina parameters, and their correlations with visual performance in patients with thalamic stroke.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We utilized resting\u2010state functional MRI to obtain multi\u2010modular functional connectivity (FC), and optical coherence tomography\u2010angiography to measure various retina parameters, such as the retinal nerve fiber layer (RNFL), ganglion cell\u2010inner plexiform layer (GCIPL), superficial vascular complex (SVC), and deep vascular complex. Visual acuity (VA) was used as a metric for visual performance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 46 patients with first\u2010ever unilateral thalamic stroke (mean age 59.74\u00a0\u00b1\u00a010.02 years, 33 males). Significant associations were found between FC of attention\u2010to\u2010default mode and SVC, RNFL, and GCIPL, as well as between FC of attention\u2010to\u2010visual and RNFL (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05). Both RNFL and GCIPL exhibited significant associations with FC of visual\u2010to\u2010visual (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05). Only GCIPL showed an association with VA (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.038). Stratified analysis based on a disease duration of 6 months revealed distinct and significant linking patterns in multi\u2010modular FC and specific retina parameters, with varying correlations with VA in each subgroup.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings provide valuable insight into the neural basis of the associations between brain network dysfunction and impaired visual performance in patients with thalamic stroke. Our novel findings have the potential to inform future targeted and individualized therapies. However, further comprehensive studies are necessary to validate our results.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.3385","type":"journal-article","created":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T02:25:35Z","timestamp":1705544735000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association between functional network connectivity, retina structure and microvasculature, and visual performance in patients after thalamic stroke: An exploratory multi\u2010modality study"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2969-5486","authenticated-orcid":false,"given":"Chen","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Neurology West China Hospital, Sichuan University  Chengdu China"},{"name":"Center of Cerebrovascular Diseases West China Hospital, Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9633-4694","authenticated-orcid":false,"given":"William Robert","family":"Kwapong","sequence":"additional","affiliation":[{"name":"Department of Neurology West China Hospital, Sichuan University  Chengdu China"},{"name":"Center of Cerebrovascular Diseases West China Hospital, Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biqiu","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Huaxi MR Research Center (HMRRC) West China Hospital, Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junfeng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology West China Hospital, Sichuan University  Chengdu China"},{"name":"Center of Cerebrovascular Diseases West China Hospital, Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendan","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Neurology West China Hospital, Sichuan University  Chengdu China"},{"name":"Center of Cerebrovascular Diseases West China Hospital, Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Neurology West China Hospital, Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruosu","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Neurology West China Hospital, Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anmo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology West China Hospital, Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lanhua","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Neurology West China Hospital, Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology West China Hospital, Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Le","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Neurology West China Hospital, Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youjie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology West China Hospital, Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuai","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Neurology West China Hospital, Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuening","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology West China Hospital, Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology West China Hospital, Sichuan University  Chengdu China"},{"name":"Center of Cerebrovascular Diseases West China Hospital, Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2067-9965","authenticated-orcid":false,"given":"Bo","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurology West China Hospital, Sichuan University  Chengdu China"},{"name":"Center of Cerebrovascular Diseases West China Hospital, Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/01658107.2011.580892"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.3652713"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000012125"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.04.042"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa101"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00201.2016"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep42201"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330\u2010019\u201006068\u20100"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2022.102953"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1006\/cbmr.1996.0014"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.12.034"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.121.034738"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001579"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00062\u2010020\u201000966\u20103"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005226"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.09.015"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e328334e99b"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr324"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21517"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.5535\/arm.2015.39.6.1033"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.787775"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.626334"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.5535\/arm.2016.40.4.751"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201096588\u2010x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2014.00074"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2016.00072"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNO.0000000000000864"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.00521"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.2345"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2018784118"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2012.243469"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.116189"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1155\/2000\/421719"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1613445114"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.06.027"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s42466\u2010021\u201000148\u20107"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.121.037750"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000087786.38997.9E"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682\u2010022\u201000708\u20108"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0034823"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.05.044"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0978"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010vision\u2010082114\u2010035920"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.004629"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2012.0073"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awac317"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.25808"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci12050518"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.942438"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8850309"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00406\u2010021\u201001344\u2010x"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.3385","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T10:39:16Z","timestamp":1710326356000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.3385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1002\/brb3.3385"],"URL":"https:\/\/doi.org\/10.1002\/brb3.3385","archive":["Portico"],"relation":{},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"type":"print","value":"2162-3279"},{"type":"electronic","value":"2162-3279"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"2023-08-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e3385"}}