{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T11:24:54Z","timestamp":1784978694013,"version":"3.55.0"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T00:00:00Z","timestamp":1705449600000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008722","name":"Universitat de Girona","doi-asserted-by":"publisher","award":["MPCUdG2016\/087"],"award-info":[{"award-number":["MPCUdG2016\/087"]}],"id":[{"id":"10.13039\/100008722","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Nociplastic pain involves reflexive and nonreflexive pain responses and it is a core symptom of fibromyalgia (FM). The increasing prevalence of this health condition and the low rates of patients\u2019 quality of life, combined with the lack of suitable pharmacologic treatments, evidence the demand to research new alternatives. Polyphenols may be potential therapeutic candidates as they have been reported to exert pathological pain modulation in preclinical models. In that context, this work was aimed to study the antinociceptive effects of a polyphenolic extract obtained from decaffeinated ground roasted coffee, in the RIM6 FM\u2010like mouse model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To this end, RIM6 adult ICR\u2010CD1 female mice were administered daily once a week with either 10 or 15\u00a0mg\/kg of extract, and reflexive pain responses were evaluated for up to 3 weeks. At the end, the depressive\u2010like behavior was assessed as a nonreflexive pain response, and spinal cord and serum samples were collected for immunohistochemical and toxicological analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>These findings showed that the repeated administration of the coffee polyphenolic extract (CE) modulated reflexive pain responses, depressive\u2010like behavior, and spinal cord gliosis in a dose\u2010dependent manner, without signs of systemic toxicity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Thus, the CE may be a potential pharmacological treatment suitable to relieve nociplastic pain responses characteristic of FM.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.3386","type":"journal-article","created":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T02:29:01Z","timestamp":1705544941000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Natural polyphenolic coffee extract administration relieves chronic nociplastic pain in a reserpine\u2010induced fibromyalgia\u2010like female mouse model"],"prefix":"10.1002","volume":"14","author":[{"given":"Rub\u00e9n","family":"Toledano\u2010Martos","sequence":"first","affiliation":[{"name":"Research Group of Clinical Anatomy, Embryology and Neuroscience (NEOMA), Department of Medical Sciences University of Girona  Girona Catalonia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Bag\u00f3\u2010Mas","sequence":"additional","affiliation":[{"name":"Research Group of Clinical Anatomy, Embryology and Neuroscience (NEOMA), Department of Medical Sciences 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