{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T03:54:34Z","timestamp":1775102074827,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,4]],"date-time":"2024-02-04T00:00:00Z","timestamp":1707004800000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["182300410389"],"award-info":[{"award-number":["182300410389"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771517"],"award-info":[{"award-number":["81771517"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2024,2]]},"abstract":"Abstract<\/jats:title>\n \n Objectives<\/jats:title>\n To investigate the correlation between serum angiopoietin\u2010like protein 4 (ANGPTL4) levels, white matter hyperintensity (WMH), and cognitive impairment (CI) in patients with cerebral small vessel disease (CSVD).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This cross\u2010sectional study enrolled 171 patients with CSVD who attended the First Affiliated Hospital of Xinxiang Medical University from December 2021 to July 2022. All subjects underwent a 3.0T head magnetic resonance imaging, neuropsychology assessment, and blood sampling. Serum ANGPTL4 levels were detected by enzyme\u2010linked immunosorbent assay and the severity of WMH was assessed by the Fazekas scale. According to the Montreal Cognitive Assessment (MoCA) scale, subjects were divided into normal cognition group (NC,\n n<\/jats:italic>\n \u00a0=\u00a080) and CI group (\n n<\/jats:italic>\n \u00a0=\u00a091). According to the total Fazekas scores, subjects were divided into a mild WMH group (\n n<\/jats:italic>\n \u00a0=\u00a084), a moderate WMH group (\n n<\/jats:italic>\n \u00a0=\u00a070), and a severe WMH group (\n n<\/jats:italic>\n \u00a0=\u00a017).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Serum ANGPTL4 levels were significantly higher in the CI group than in the NC group (\n p<\/jats:italic>\n \u00a0<\u00a0.05) and were negatively correlated with mini\u2013mental state examination scores and MoCA scores (\n r<\/jats:italic>\n \u00a0=\u00a0\u22120.26, \u22120.341,\n p<\/jats:italic>\n \u00a0<\u00a0.05). Serum ANGPTL4 levels increased significantly in the mild to moderate WMH group but tended to decrease in the severe WMH group. Binary logistic regression analysis showed that ANGPTL4 was an independent influencing factor for CSVD\u2010CI (OR\u00a0=\u00a02.062, 95% CI (1.591\u20132.674),\n p<\/jats:italic>\n \u00a0<\u00a0.001). The area under curve of ANGPTL4 for CSVD\u2010CI was 0.847 (0.791\u20130.903).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n ANGPTL4 may be involved in the process of white matter damage and CI in CSVD patients and shows a diagnostic value for CSVD\u2010CI.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/brb3.3401","type":"journal-article","created":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T00:06:31Z","timestamp":1707091591000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Correlation between serum ANGPTL4 levels and white matter hyperintensity and cognitive impairment in patients with cerebral small vessel disease"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0808-9834","authenticated-orcid":false,"given":"Jianhua","family":"Zhao","sequence":"first","affiliation":[{"name":"Henan Joint International Research Laboratory of Neurorestoratology for Senile Dementia, Henan Key Laboratory of Neurorestoratology, Department of Neurology First Affiliated Hospital of Xinxiang Medical University Xinxiang Henan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiyun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Henan Joint International Research Laboratory of Neurorestoratology for Senile Dementia, Henan Key Laboratory of Neurorestoratology, Department of Neurology First Affiliated Hospital of Xinxiang Medical University Xinxiang Henan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoting","family":"Wang","sequence":"additional","affiliation":[{"name":"Henan Joint International Research Laboratory of Neurorestoratology for Senile Dementia, Henan Key Laboratory of Neurorestoratology, Department of Neurology First Affiliated Hospital of Xinxiang Medical University Xinxiang Henan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minghua","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology Beijing Tiantan Hospital, Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zehua","family":"Wang","sequence":"additional","affiliation":[{"name":"Henan Joint International Research Laboratory of Neurorestoratology for Senile Dementia, Henan Key Laboratory of Neurorestoratology, Department of Neurology First Affiliated Hospital of Xinxiang Medical University Xinxiang Henan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruotai","family":"Li","sequence":"additional","affiliation":[{"name":"Henan Joint International Research Laboratory of Neurorestoratology for Senile Dementia, Henan Key Laboratory of Neurorestoratology, Department of Neurology First Affiliated Hospital of Xinxiang Medical University Xinxiang Henan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxi","family":"Liu","sequence":"additional","affiliation":[{"name":"Henan Joint International Research Laboratory of Neurorestoratology for Senile Dementia, Henan Key Laboratory of Neurorestoratology, Department of Neurology First Affiliated Hospital of Xinxiang Medical University Xinxiang Henan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengbiao","family":"Lu","sequence":"additional","affiliation":[{"name":"Henan International Joint Laboratory of Non\u2010Invasive Neuromodulation, Department of Physiology and Neurobiology Xinxiang Medical University Xinxiang Henan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaomin","family":"Li","sequence":"additional","affiliation":[{"name":"Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital Harvard Medical School Boston Massachusetts 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