{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:47:41Z","timestamp":1793123261641,"version":"4.5.0"},"reference-count":76,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T00:00:00Z","timestamp":1707436800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The primary aim of this study was to assess changes in sleep\u2010specific health\u2010related quality of life (HRQoL) for those prescribed cannabis\u2010based medicinal products (CBMPs) for insomnia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A case series of UK patients with insomnia was analyzed. Primary outcomes were changes in the Single\u2010Item Sleep\u2010Quality Scale (SQS), Generalized Anxiety Disorder\u20107 (GAD\u20107), and EQ\u20105D\u20105L at up to 6 months from baseline. Statistical significance was identified as a\n                      <jats:italic>p<\/jats:italic>\n                      value &lt; .050.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      61 patients were included in the analysis. There was an improvement in the SQS from baseline at 1, 3, and 6 months (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; .001). There were also improvements in the EQ\u20105D\u20105L Index value and GAD\u20107 at 1, 3, and 6 months (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; .050). There were 28 (45.9%) adverse events recorded by 8 patients (13.1%). There were no life\u2010threatening\/disabling adverse events.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients with insomnia experienced an improvement in sleep quality following the initiation of CBMPs in this medium\u2010term analysis. Fewer than 15% of participants reported one or more adverse events. However, due to the limitations of the study design, further investigation is required before definitive conclusions can be drawn on the efficacy of CBMPs in treating insomnia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.3410","type":"journal-article","created":{"date-parts":[[2024,2,10]],"date-time":"2024-02-10T00:50:10Z","timestamp":1707526210000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["UK Medical Cannabis Registry: Assessment of clinical outcomes in patients with insomnia"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1815-6460","authenticated-orcid":false,"given":"Kavyesh","family":"Vivek","sequence":"first","affiliation":[{"name":"Imperial College Medical Cannabis Research Group, Department of Surgery and Cancer Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zekiye","family":"Karagozlu","sequence":"additional","affiliation":[{"name":"Imperial College Medical Cannabis Research Group, Department of Surgery and Cancer Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5871-6501","authenticated-orcid":false,"given":"Simon","family":"Erridge","sequence":"additional","affiliation":[{"name":"Imperial College Medical Cannabis Research Group, Department of Surgery and Cancer Imperial College London London UK"},{"name":"Department of Medicine Curaleaf Clinic London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl","family":"Holvey","sequence":"additional","affiliation":[{"name":"Department of Medicine Curaleaf Clinic London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross","family":"Coomber","sequence":"additional","affiliation":[{"name":"Department of Medicine Curaleaf Clinic London UK"},{"name":"Department of Trauma and Orthopaedics St. George's\u00a0Hospital NHS Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James J.","family":"Rucker","sequence":"additional","affiliation":[{"name":"Department of Medicine Curaleaf Clinic London UK"},{"name":"Department of Psychological Medicine Kings College London London UK"},{"name":"National and Specialist Tertiary Referrals Affective Disorders Service South London &amp; Maudsley NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark W.","family":"Weatherall","sequence":"additional","affiliation":[{"name":"Department of Medicine Curaleaf Clinic London UK"},{"name":"Department of Neurology Buckinghamshire Healthcare NHS Trust Amersham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael H","family":"Sodergren","sequence":"additional","affiliation":[{"name":"Imperial College Medical Cannabis Research Group, Department of Surgery and Cancer Imperial College London London UK"},{"name":"Department of Medicine Curaleaf Clinic London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/SLEEP\/ZSAB234"},{"key":"e_1_2_10_3_1","volume-title":"Diagnostic and statistical manual of mental disorders (DSM\u20105\u00ae)","author":"APA","year":"2013"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/S11920\u2010017\u20100775\u20109\/TABLES\/1"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/S11065\u2010011\u20109160\u20103"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/S10964\u2010014\u20100248\u2010Y"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215\u20100366(19)30401\u20108"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CPR.2018.05.006"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.SMRV.2013.02.003"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1099\u20101050(199902)8:1<41::aid\u2010hec395>3.0.co;2\u2010#"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3414\/ME17\u201001\u20100051"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/MEDLAW\/FWAA002"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-9586-8"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021\u20109681(87)90171\u20108"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/S12877\u2010020\u201001838\u20108"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00228\u2010012\u20101424\u20101"},{"key":"e_1_2_10_17_1","volume-title":"Left behind: The scale of illegal cannabis use for medicinal intent in the UK","author":"Couch D. 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