{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:05:27Z","timestamp":1753862727687,"version":"3.41.2"},"reference-count":67,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,17]],"date-time":"2024-03-17T00:00:00Z","timestamp":1710633600000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Communication skills can deteriorate in neurodegenerative diseases such as Alzheimer's disease (AD) and frontotemporal dementia (FTD); however, their clinical assessment and treatment in patient care can be challenging. In the present study, we aimed to quantify the distinctive communication resources and barriers reported by patients and their relatives in AD and FTD and associated these communicative characteristics with clinical parameters, such as the degree of cognitive impairment and atrophy in language\u2010associated brain areas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We assessed self\u2010reported communication barriers and resources in 33 individuals with AD and FTD through an interview on daily\u2010life communication, using the <jats:italic>Aachener KOMPASS<\/jats:italic> questionnaire. We correlated reported communication barriers and resources with atrophy from high\u2010resolution 3T brain magnetic resonance imaging, neuropsychological assessment, and neurodegenerative markers from cerebrospinal fluid.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Communicative impairment was higher in FTD compared to AD. Increased reported communication barriers in our whole sample were associated with the atrophy rate in the left middle temporal lobe, a critical site within the neuronal language network, and with depressive symptoms as well as the semantic word fluency from neuropsychological assessment. The best model for prediction of communicative impairment included the diagnosis (AD or FTD), semantic word fluency, and depressive symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study demonstrates that communication barriers and resources can be successfully assessed via a structured interview based on self\u2010report and report of patients\u2019 relatives in practice and are reflected in neuroimaging specific for AD and FTD as well as in further clinical parameters specific for these neurodegenerative diseases. This can potentially open new treatment options for clinical practice and patient care.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.3420","type":"journal-article","created":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T06:16:17Z","timestamp":1710742577000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Communicative impairment and its neural correlates in Alzheimer's disease and frontotemporal dementia"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2927-4016","authenticated-orcid":false,"given":"Alexa","family":"Haeger","sequence":"first","affiliation":[{"name":"Department of Neurology RWTH Aachen University Aachen Germany"},{"name":"JARA\u2010BRAIN Institute Molecular Neuroscience and Neuroimaging Forschungszentrum J\u00fclich GmbH and RWTH Aachen University  Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janka","family":"Muising","sequence":"additional","affiliation":[{"name":"Department of Neurology RWTH Aachen University Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandro","family":"Romanzetti","sequence":"additional","affiliation":[{"name":"Department of Neurology RWTH Aachen University Aachen Germany"},{"name":"JARA\u2010BRAIN Institute Molecular Neuroscience and Neuroimaging Forschungszentrum J\u00fclich GmbH and RWTH Aachen University  Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Fimm","sequence":"additional","affiliation":[{"name":"Department of Neurology RWTH Aachen University Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Matz","sequence":"additional","affiliation":[{"name":"Department of Neurology RWTH Aachen University Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg B.","family":"Schulz","sequence":"additional","affiliation":[{"name":"Department of Neurology RWTH Aachen University Aachen Germany"},{"name":"JARA\u2010BRAIN Institute Molecular Neuroscience and Neuroimaging Forschungszentrum J\u00fclich GmbH and RWTH Aachen University  Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Heim","sequence":"additional","affiliation":[{"name":"Department of Neurology RWTH Aachen University Aachen Germany"},{"name":"Institute of Neuroscience and Medicine (INM\u20101) Research Centre J\u00fclich  J\u00fclich Germany"},{"name":"Department of Psychiatry, Psychotherapy and Psychosomatics, Medical Faculty RWTH Aachen University  Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathrin","family":"Reetz","sequence":"additional","affiliation":[{"name":"Department of Neurology RWTH Aachen University Aachen Germany"},{"name":"JARA\u2010BRAIN Institute Molecular Neuroscience and Neuroimaging Forschungszentrum J\u00fclich GmbH and RWTH Aachen University  Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,3,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000210435.72614.38"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandl.2019.04.006"},{"key":"e_1_2_10_4_1","unstructured":"ASHA. 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